1,4-双(三氯甲基)苯合成路线 （共 30 条）
参考文献
Rabjohn
Journal of the American Chemical Society, 1954 , vol. 76, p. 5479,5481
参考文献
Bock, Hans; Meuret, Jochen; Baur, Ruediger; Ruppert, Klaus
Journal of Organometallic Chemistry, 1993 , vol. 446, # 1.2 p. 113 - 122
反应条件
hydrogen fluoride in 1,2-dichloro-ethane T=45°C; P=2280.15 Torr; 10 h;
参考文献
Dolbier Jr., William R.; Duan, Jian-Xin; Rong, Xiao X.
Journal of Fluorine Chemistry, 2007 , vol. 128, # 10 p. 1091 - 1093
参考文献
Colson; Gautier
Bulletin de la Societe Chimique de France, 1886 , vol. <2> 45, p. 509
Annales de Chimie (Cachan, France), 1887 , vol. <6> 11, p. 26
反应条件
1: 56 percent / 1,3-benzenedicarboxylic acid, ZnCl2 / 4.5 h / 185 °C
2: 99 percent / lithium tri-tert-butoxyaluminum hydride, 2-ethoxyethanol, carbon dioxide / tetrahydrofuran / 1 h / -65 °C
View Scheme
参考文献
Morkved; Cronyn
Journal of Pharmaceutical Sciences, 1982 , vol. 71, # 1 p. 59 - 63
反应条件
1: 56 percent / 1,3-benzenedicarboxylic acid, ZnCl2 / 4.5 h / 185 °C
2: 99 percent / lithium tri-tert-butoxyaluminum hydride, 2-ethoxyethanol, carbon dioxide / tetrahydrofuran / 1 h / -65 °C
3: 65 percent / p-toluenesulfonic acid / benzene / 3 h / Heating
View Scheme
参考文献
Morkved; Cronyn
Journal of Pharmaceutical Sciences, 1982 , vol. 71, # 1 p. 59 - 63
反应条件
PPA
T=100 - 150°C; Addition; 6 h;
参考文献
So, Ying-Hung; DeCaire, Richard
Synthetic Communications, 1998 , vol. 28, # 22 p. 4123 - 4135
反应条件
pyridine in ethanol
21 h; Heating;
参考文献
Belen'kii; Luiksaar; Poddubnyi; Krayushkin
Russian Chemical Bulletin, 1998 , vol. 47, # 11 p. 2238 - 2245
反应条件
1: aq. FeCl3
2: aq. Et3N
View Scheme
参考文献
Yagupol'skii,L.M.; Malichenko,B.F.
J. Gen. Chem. USSR (Engl. Transl.), 1962 , vol. 32, # 9 p. 3035 - 3039,2985 - 2988
