1-[4-[2-(二甲基氨基)乙氧基]苯基]-2-苯基-1-丁酮合成路线 （共 11 条）
反应条件
hydrogenchloride in tetrahydrofuran; ethanol; hexane
参考文献
National Research Development Corporation
Patent: US4839155 A1, 1989 ;
US 4839155 A
反应条件
1: 1) n-BuLi / 1) THF, hexane, -75 deg C, 10 min, 2) THF, r.t., 16 h 2: conc. HCl / ethanol / 20 h / Heating 3: 1) t-BuLi, 2) H2O / 1) THF, -75 deg C View Scheme
参考文献
McCague, Raymond
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 1011 - 1016
反应条件
2: cc. HCl / ethanol / 0.33 h / Heating 3: cc. HCl / ethanol / 4 h / Heating View Scheme
参考文献
McCague, Raymond
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 1011 - 1016
参考文献
Catalytica Pharmaceuticals, Inc.
Patent: US5962743 A1, 1999 ;
反应条件
1: 85 percent / (n-Bu)4N(+)HSO4(-) / 1.) 3M aq. NaOH, reflux, 1 h, 2.) 6M aq. NaOH, reflux, 1 h
2: 94 percent / (CF3CO)2O / 70 h / 20 °C
3: 96 percent / ethanol / 68 h / Heating
View Scheme
参考文献
McCague, Raymond
Journal of Chemical Research, Miniprint, 1986 , # 2 p. 771 - 793
反应条件
in ethanol
68 h; Heating;
参考文献
McCague, Raymond
Journal of Chemical Research, Miniprint, 1986 , # 2 p. 771 - 793
反应条件
1: 94 percent / (CF3CO)2O / 70 h / 20 °C
2: 96 percent / ethanol / 68 h / Heating
View Scheme
参考文献
McCague, Raymond
Journal of Chemical Research, Miniprint, 1986 , # 2 p. 771 - 793
参考文献
Di Paco; Tauro
Annali di Chimica (Rome, Italy), 1958 , vol. 48, p. 1215,1223
反应条件
1: Py*HCl / Heating
2: (i) NaOEt, EtOH, (ii) /BRN= 605280/, benzene
View Scheme
参考文献
Imperial Chemical Industries, Ltd.
Patent: BE637389 , 1964 ;
Chem.Abstr., 1965 , vol. 62, # 10373
反应条件
(i) NaOEt, EtOH, (ii) /BRN= 605280/, benzene; Multistep reaction;
参考文献
Imperial Chemical Industries, Ltd.
Patent: BE637389 , 1964 ;
Chem.Abstr., 1965 , vol. 62, # 10373
