1-ethyl-2-pyrrolidinone; 4-(N,N-dimethlyamino)pyridine; phosphonic acid diethyl ester; nickel dichloride; zinc dibromide in tetrahydrofuran T=20°C; 1 h;

1: 3-fluoro-1-bromobenzene With magnesium in tetrahydrofuran 2: With zinc dibromide in tetrahydrofuran 3: 5-bromo-pyrimidine With 4-(N,N-dimethlyamino)pyridine; phosphonic acid diethyl ester; nickel dichloride in tetrahydrofuran T=25°C; Negishi cross-coupling; 1 h;