1.1: hydrogenchloride / methanol; water / 2 h / 75 °C / |Inert atmosphere 2.1: sodium nitrite / water / 1.25 h / 0 - 5 °C / |Inert atmosphere 2.2: 1 h / 0 - 65 °C 2.3: 1 h / 40 - 50 °C 3.1: sodium acetate / methanol / 1.33 h / -10 - 0 °C 4.1: acetic acid / ethyl acetate / 4 h / 65 - 70 °C View Scheme

1.1: chlorine 2.1: hydrogenchloride / methanol; water / 2 h / 75 °C / |Inert atmosphere 3.1: sodium nitrite / water / 1.25 h / 0 - 5 °C / |Inert atmosphere 3.2: 1 h / 0 - 65 °C 3.3: 1 h / 40 - 50 °C 4.1: sodium acetate / methanol / 1.33 h / -10 - 0 °C 5.1: acetic acid / ethyl acetate / 4 h / 65 - 70 °C View Scheme

1.1: sodium methylate; bromine / methanol / 0.5 h / 0 - 5 °C 1.2: 55 - 60 °C 2.1: hydrogenchloride / toluene / 3 h / 10 - 20 °C / |Inert atmosphere 3.1: sodium acetate / methanol / 1.33 h / -10 - 0 °C 4.1: acetic acid / ethyl acetate / 4 h / 65 - 70 °C View Scheme

1.1: sodium nitrite / water / 1.25 h / 0 - 5 °C / |Inert atmosphere 1.2: 1 h / 0 - 65 °C 1.3: 1 h / 40 - 50 °C 2.1: sodium acetate / methanol / 1.33 h / -10 - 0 °C 3.1: acetic acid / ethyl acetate / 4 h / 65 - 70 °C View Scheme

1.1: manganese(IV) oxide; water / 120 - 135 °C / |Inert atmosphere 2.1: sodium methylate; bromine / methanol / 0.5 h / 0 - 5 °C 2.2: 55 - 60 °C 3.1: hydrogenchloride / toluene / 3 h / 10 - 20 °C / |Inert atmosphere 4.1: sodium acetate / methanol / 1.33 h / -10 - 0 °C 5.1: acetic acid / ethyl acetate / 4 h / 65 - 70 °C View Scheme

1: hydrogenchloride / toluene / 3 h / 10 - 20 °C / |Inert atmosphere 2: sodium acetate / methanol / 1.33 h / -10 - 0 °C 3: acetic acid / ethyl acetate / 4 h / 65 - 70 °C View Scheme

potassium carbonate; potassium hydroxide in water; acetone T=60 - 65°C; 0.5 h;