N-甲氧基-N-甲基-3-溴-2-氟苯甲酰胺合成路线 （共 4 条）
反应条件
1: in tetrahydrofuran; diethyl ether; dichloromethane T=-78 - 20°C; 2: With hydrogenchloride in tetrahydrofuran; diethyl ether; water T=0°C; pH=1;
参考文献
Andreini, Matteo; Gabellieri, Emanuele; Guba, Wolfgang; Marconi, Guido; Narquizian, Robert; Power, Eoin; Travagli, Massimiliano; Woltering, Thomas; Wostl, Wolfgang
Patent: US2009/209529 A1, 2009 ;
Location in patent: Page/Page column 34 ;
反应条件
1: 3-bromo-2-fluorobenzoic acid With 1,1'-carbonyldiimidazole in dichloromethane
1 h; HeatingReflux;
2: O,N-dimethyl-hydroxylamine hydrochloride With triethylamine in dichloromethane
T=20°C;
参考文献
Andreini, Matteo; Gabellieri, Emanuele; Guba, Wolfgang; Marconi, Guido; Narquizian, Robert; Power, Eoin; Travagli, Massimiliano; Woltering, Thomas; Wostl, Wolfgang
Patent: US2009/209529 A1, 2009 ;
Location in patent: Page/Page column 34 ;
反应条件
N-ethyl-N,N-diisopropylamine in tetrahydrofuran; N,N-dimethyl-formamide
T=20°C;
参考文献
ASTRAZENECA AB; SCHERING AG
Patent: WO2007/46747 A1, 2007 ;
Location in patent: Page/Page column 66-67 ;
WO 2007/046747 A1
反应条件
1: O,N-dimethyl-hydroxylamine hydrochloride With triethylamine in dichloromethane
T=0°C; Inert atmosphere;
2: 3-bromo-2-fluorobenzoyl chloride in dichloromethane
T=0 - 20°C; Inert atmosphere;
参考文献
Kishore Kumar; Chavarria, Gustavo E.; Charlton-Sevcik, Amanda K.; Arispe, Wara M.; MacDonough, Matthew T.; Strecker, Tracy E.; Chen, Shen-En; Siim, Bronwyn G.; Chaplin, David J.; Trawick, Mary Lynn; Pinney, Kevin G.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 4 p. 1415 - 1419
