3-(2,4-二甲氧基苯基)-7-三氟甲基-1H-吲唑合成路线 （共 7 条）
反应条件
pyridine; hydrazine
T=100°C; 1 h; Microwave irradiation;
参考文献
Murray, Iain A.; Krishnegowda, Gowdahalli; Dinatale, Brett C.; Flaveny, Colin; Chiaro, Chris; Lin, Jyh-Ming; Sharma, Arun K.; Amin, Shantu; Perdew, Gary H.
Chemical Research in Toxicology, 2010 , vol. 23, # 5 p. 955 - 966
反应条件
tetrabutylammomium bromide; sodium hydride in N,N-dimethyl-formamide
T=110°C; Inert atmosphereSchlenk technique;
参考文献
Liu, Zhenxing; Wang, Long; Tan, Haocheng; Zhou, Shiyi; Fu, Tianren; Xia, Ying; Zhang, Yan; Wang, Jianbo
Chemical Communications, 2014 , vol. 50, # 39 p. 5061 - 5063
反应条件
1: 4-methyl-morpholine / tetrahydrofuran / 1 h / 20 °C
2: 8 h / 20 °C
3: tetrahydrofuran / 2 h / 0 °C
4: pyridine; hydrazine / 1 h / 100 °C / Microwave irradiation
View Scheme
参考文献
Murray, Iain A.; Krishnegowda, Gowdahalli; Dinatale, Brett C.; Flaveny, Colin; Chiaro, Chris; Lin, Jyh-Ming; Sharma, Arun K.; Amin, Shantu; Perdew, Gary H.
Chemical Research in Toxicology, 2010 , vol. 23, # 5 p. 955 - 966
反应条件
1: tetrahydrofuran / 2 h / 0 °C
2: pyridine; hydrazine / 1 h / 100 °C / Microwave irradiation
View Scheme
参考文献
Murray, Iain A.; Krishnegowda, Gowdahalli; Dinatale, Brett C.; Flaveny, Colin; Chiaro, Chris; Lin, Jyh-Ming; Sharma, Arun K.; Amin, Shantu; Perdew, Gary H.
Chemical Research in Toxicology, 2010 , vol. 23, # 5 p. 955 - 966
反应条件
1: tetrahydrofuran / 2 h / 0 °C
2: pyridine; hydrazine / 1 h / 100 °C / Microwave irradiation
View Scheme
参考文献
Murray, Iain A.; Krishnegowda, Gowdahalli; Dinatale, Brett C.; Flaveny, Colin; Chiaro, Chris; Lin, Jyh-Ming; Sharma, Arun K.; Amin, Shantu; Perdew, Gary H.
Chemical Research in Toxicology, 2010 , vol. 23, # 5 p. 955 - 966
反应条件
sodium hydride in DMF (N,N-dimethyl-formamide)
T=20 - 50°C;
参考文献
Wyeth
Patent: US2006/111421 A1, 2006 ;
Location in patent: Page/Page column 15-16 ;
反应条件
1: 3-(2,4-dimethoxyphenyl)-7-(trifluoromethyl)-1H-indazole With sodium hydride in N,N-dimethyl-formamide; mineral oil
T=20 - 60°C;
2: allyl bromide in N,N-dimethyl-formamide; mineral oil
T=60°C; 4 h;
参考文献
Murray, Iain A.; Krishnegowda, Gowdahalli; Dinatale, Brett C.; Flaveny, Colin; Chiaro, Chris; Lin, Jyh-Ming; Sharma, Arun K.; Amin, Shantu; Perdew, Gary H.
Chemical Research in Toxicology, 2010 , vol. 23, # 5 p. 955 - 966
