N-叔丁氧羰基-1,4-丁二胺合成路线 （共 29 条）
反应条件
1: 90 percent / methanol / 12 h / 0 - 20 °C 2: 92 percent / CH2Cl2 / 4.5 h / 20 °C 3: 65 percent / LiAlH4 / diethyl ether / 3 h / 0 - 20 °C View Scheme
参考文献
Biological and Pharmaceutical Bulletin, , vol. 30, # 6 p. 1117 - 1122
参考文献
WO2008/125615 A1, ;
Page/Page column 42 ;
反应条件
1: 75 percent / TEA / tetrahydrofuran / Ambient temperature 2: NaOH, H2O / dioxane; methanol / 0.5 h / Ambient temperature 3: HCl, H2O, TEA / acetonitrile / 0.5 h View Scheme
参考文献
Jahnsen, Rasmus D.; Frimodt-Moller, Niels; Franzyk, Henrik
Journal of Medicinal Chemistry, 2012 , vol. 55, # 16 p. 7253 - 7261
反应条件
1: With potassium carbonate in methanol
6 h;
2: With sodium tetrahydroborate in methanol
T=0°C; 0.75 h;
参考文献
Bridger, Gary; McEachern, Ernest J.; Skerlj, Renato; Schols, Dominique
Patent: US2004/209921 A1, 2004 ;
Location in patent: Page 97 ;
US 20040209921 A1
反应条件
in methanol
T=0°C; 1.5 h;
参考文献
HUNTER-FLEMING LIMITED
Patent: WO2005/116050 A1, 2005 ;
Location in patent: Page/Page column 30 ;
反应条件
potassium carbonate in acetonitrile
T=50°C; 24 h;
参考文献
Gardner, Richard Andrew; Kinkade, Rebecca; Wang, Chaojie; Phanstiel IV, Otto
Journal of Organic Chemistry, 2004 , vol. 69, # 10 p. 3530 - 3537
参考文献
Beria, Italo; Baraldi, Pier Giovanni; Cozzi, Paolo; Caldarelli, Marina; Geroni, Cristina; Marchini, Sergio; Mongelli, Nicola; Romagnoli, Romeo
Journal of Medicinal Chemistry, 2004 , vol. 47, # 10 p. 2611 - 2623
反应条件
1: 82 percent / aq. NaOH / 16 h / 0 - 20 °C
2: 76 percent / TFA / CH2Cl2 / 1 h / 0 °C
View Scheme
参考文献
Blagbrough, Ian S.; Moya, Eduardo; Walford, Steven P.
Tetrahedron Letters, 1996 , vol. 37, # 4 p. 551 - 554
反应条件
in acetonitrile
T=20°C;
参考文献
Ran, Chongzhao; Pantazopoulos, Pamela; Medarova, Zdravka; Moore, Anna
Angewandte Chemie - International Edition, 2007 , vol. 46, # 47 p. 8998 - 9001
