3,5-二丁基-6-(1-丁基-2-氧代庚基)-4-羟基-2H-吡喃-2-酮; 抑弹朊酶素合成路线 （共 9 条）
反应条件
pyridine; chromium(VI) oxide in acetone
T=0 - 20°C;
参考文献
Shone; Deason; Miyano
Journal of Organic Chemistry, 1986 , vol. 51, # 2 p. 268 - 270
反应条件
sulfuric acid
T=0°C; 0.0833333 h;
参考文献
Pfister, Juerg R.
Tetrahedron Letters, 1980 , vol. 21, p. 1281 - 1284
反应条件
1: 88 percent / m-chloroperoxybenzoic acid, 4,4'-thiobis-(6-t-butyl-3-methylphenol) / 1,2-dichloro-ethane / 9 h / Ambient temperature
2: H2 / 10percent Pd-C / ethanol / Ambient temperature
3: oxidation with Jones reagent
4: 92 percent / conc. H2SO4 / 0.08 h / 0 °C
View Scheme
参考文献
Pfister, Juerg R.
Tetrahedron Letters, 1980 , vol. 21, p. 1281 - 1284
反应条件
1: H2 / 10percent Pd-C / ethanol / Ambient temperature
2: oxidation with Jones reagent
3: 92 percent / conc. H2SO4 / 0.08 h / 0 °C
View Scheme
参考文献
Pfister, Juerg R.
Tetrahedron Letters, 1980 , vol. 21, p. 1281 - 1284
反应条件
1: 1.) lithium diisopropylamide / 1.) THF, 0 deg C, 1 h, 2.) THF, -78 deg C, 1 h
2: 79 percent / 90percent H2SO4 / Ambient temperature
4: 65 percent / CrO3, pyridine / acetone / 0 - 20 °C
View Scheme
参考文献
Shone; Deason; Miyano
Journal of Organic Chemistry, 1986 , vol. 51, # 2 p. 268 - 270
反应条件
1: 1.) lithium diisopropylamide / 1.) THF, 0 deg C, 1 h, 2.) THF, -78 deg C, 1 h
2: 79 percent / 90percent H2SO4 / Ambient temperature
4: 65 percent / CrO3, pyridine / acetone / 0 - 20 °C
View Scheme
参考文献
Shone; Deason; Miyano
Journal of Organic Chemistry, 1986 , vol. 51, # 2 p. 268 - 270
反应条件
2: 65 percent / CrO3, pyridine / acetone / 0 - 20 °C
View Scheme
参考文献
Shone; Deason; Miyano
Journal of Organic Chemistry, 1986 , vol. 51, # 2 p. 268 - 270
反应条件
1: 79 percent / 90percent H2SO4 / Ambient temperature
3: 65 percent / CrO3, pyridine / acetone / 0 - 20 °C
View Scheme
参考文献
Shone; Deason; Miyano
Journal of Organic Chemistry, 1986 , vol. 51, # 2 p. 268 - 270
反应条件
1: oxidation with Jones reagent
2: 92 percent / conc. H2SO4 / 0.08 h / 0 °C
View Scheme
参考文献
Pfister, Juerg R.
Tetrahedron Letters, 1980 , vol. 21, p. 1281 - 1284
