1-(3,4-二氯苯基)-1-戊酮合成路线 （共 4 条）
反应条件
1: in tetrahydrofuran
T=0 - 20°C; 144 h; Inert atmosphere;
2: With hydrogenchloride in tetrahydrofuran; water
T=0°C;
参考文献
RESEARCH TRIANGLE INSTITUTE; CARROLL, Frank Ivy; BLOUGH, Bruce; ABRAHAM, Philip
Patent: WO2010/121022 A1, 2010 ;
Location in patent: Page/Page column 61-62 ;
WO 2010/121022 A1
反应条件
1: in tetrahydrofuran
T=0 - 20°C; Inert atmosphere;
2: With hydrogenchloride; water in tetrahydrofuran
T=0 - 20°C;
参考文献
Carroll, F. Ivy; Blough, Bruce E.; Abraham, Philip; Mills, Andrew C.; Holleman, J. Ashley; Wolckenhauer, Scott A.; Decker, Ann M.; Landavazo, Antonio; McElroy, K. Timothy; Navarro, Hernan A.; Gatch, Michael B.; Forster, Michael J.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 21 p. 6768 - 6781
反应条件
AlCl3, aluminium chloride
T=80°C; 5.5 h;
参考文献
F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; ADAM, Jean-Michel; DVORAK, Charles Alois; FISHLOCK, Daniel; HUMPHREYS, Eric R.; IDING, Hans; PFLEGER, Christophe; REGE, Pankaj D.; SHI, Xianqing; VITALE, Justin; WANG, Shaoning; ZAJAC, Marian
Patent: WO2013/160273 A1, 2013 ;
Location in patent: Page/Page column 68; 69 ;
反应条件
bis-triphenylphosphine-palladium(II) chloride; potassium phosphate in toluene
T=80°C;
参考文献
Fujii, Naoaki; Mallari, Jeremy P.; Hansell, Elizabeth J.; MacKey; Doyle, Patricia; Zhou; Gut, Jiri; Rosenthal, Philip J.; McKerrow, James H.; Guy, R. Kiplin
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 1 p. 121 - 123
