反应条件
1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
1.2: 13 h / -78 - 20 °C / Inert atmosphere
2.1: potassium hydroxide / methanol; water / 1 h / Reflux
View Scheme
参考文献
Billamboz, Muriel; Bailly, Fabrice; Lion, Cedric; Calmels, Christina; Andreola, Marie-Line; Witvrouw, Myriam; Christ, Frauke; Debyser, Zeger; De Luca, Laura; Chimirri, Alba; Cotelle, Philippe
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 535 - 546
