1: With lithium hexamethyldisilazane; tris-(dibenzylideneacetone)dipalladium(0); biphenyl-2-yl-di-tert-butyl-phosphane in tetrahydrofuran
T=65°C; 2 h;
2: With hydrogenchloride in tetrahydrofuran; water
T=20°C; pH=7;
参考文献
ARENA PHARMACEUTICALS, INC.
Patent: WO2005/7658 A2, 2005 ;
Location in patent: Page 215 ;
WO 2005/007658 A2