4,5-双-(对氟苯基)咪唑合成路线 （共 2 条）
反应条件
1: 0.5 h; Reflux;
2: With hydrogenchloride in water
T=80 - 90°C;
3: With ammonium hydroxide in water
参考文献
Liu, Wukun; Bensdorf, Kerstin; Hagenbach, Adelheid; Abram, Ulrich; Niu, Ben; Mariappan, Aruljothi; Gust, Ronald
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 12 p. 5927 - 5934
反应条件
1.1: thiamine chloride hydrochloride; sodium hydroxide / ethanol; water / 20 °C / pH 9 - 10
2.1: 0.5 h / Reflux
2.2: 80 - 90 °C
View Scheme
参考文献
Liu, Wukun; Bensdorf, Kerstin; Hagenbach, Adelheid; Abram, Ulrich; Niu, Ben; Mariappan, Aruljothi; Gust, Ronald
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 12 p. 5927 - 5934
