反应条件
1: 3,6-dioxa-4-lt;(allyloxy)methylgt;-1,8-octanediol With sodium hydride in DMF (N,N-dimethyl-formamide)
1.5 h;
2: 2-(2-bromoethoxy)-2H-tetrahydropyran in DMF (N,N-dimethyl-formamide)
48 h; Heating / reflux;
3: With hydrogenchloride in methanol; dichloromethane
48 h;
参考文献
IBC Advanced Technologies, Inc.
Patent: US6686479 B2, 2004 ;
Location in patent: Page column 11; 12 ;