1-氨基-2-乙烯基-环丙羧酸乙酯盐酸盐合成路线 （共 6 条）
反应条件
1: T=20°C; Heating / reflux; 2: With hydrogenchloride in water T=20°C; 2 h;
参考文献
Bristol-Myers Squibb Company
Patent: US2008/14173 A1, 2008 ;
Location in patent: Page/Page column 21 ;
US 20080014173 A1
反应条件
hydrogenchloride in 1,4-dioxane
T=20°C; 2 h;
参考文献
Bristol-Myers Squibb Company
Patent: US2008/14173 A1, 2008 ;
Location in patent: Page/Page column 21 ;
US 20080014173 A1
反应条件
1: With water in tert-butyl methyl ether
2: With hydrogenchloride in water
T=20°C; 2 h;
3: With sodium hydroxide in tert-butyl methyl ether; water
T=0°C; pH=14;
参考文献
Bristol-Myers Squibb Company
Patent: US2008/14173 A1, 2008 ;
Location in patent: Page/Page column 21 ;
US 20080014173 A1
反应条件
hydrogenchloride in diethyl ether; water
T=20°C; 3.5 h; Product distribution / selectivity;
参考文献
Bristol-Myers Squibb Company
Patent: US2008/107625 A1, 2008 ;
Location in patent: Page/Page column 20 ;
反应条件
hydrogenchloride in 1,4-dioxane
Product distribution / selectivity;
参考文献
Bristol-Myers Squibb Company
Patent: US2008/14173 A1, 2008 ;
Location in patent: Page/Page column 21-22 ;
US 20080014173 A1
反应条件
sodium hydroxide
pH=14;
参考文献
Bristol-Myers Squibb Company
Patent: US2008/107625 A1, 2008 ;
Location in patent: Page/Page column 20 ;
