2-叔丁基-1H-吲哚-5-胺合成路线 （共 5 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol
P=2172.08 Torr; 2.25 h;
参考文献
Rigel pharmaceuticals, Inc.
Patent: WO2004/35571 A1, 2004 ;
Location in patent: Page 25 ;
反应条件
1: 86 percent / NaNO3, H2SO4 / 1.) 0 deg C, 5 h, 2.) RT, 12 h
2: H2 / 10percent Pd/C / methanol / 2 h / 2068.6 Torr
View Scheme
参考文献
Kuyper, Lee F.; Baccanari, David P.; Jones, Michael L.; Hunter, Robert N.; Tansik, Robert L.; Joyner, Suzanne S.; Boytos, Christine M.; Rudolph, Sharon K.; Knick, Vince; Wilson, H. Robert; Caddell, J. Marc; Friedman, Henry S.; Comley, John C. W.; Stables, Jeremy N.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 4 p. 892 - 903
反应条件
1: Pd(PPh3)2Cl2, Et3N, CuI / dimethylformamide / 48 h / Ambient temperature
2: CuI / dimethylformamide / 4 h / Heating
3: 86 percent / NaNO3, H2SO4 / 1.) 0 deg C, 5 h, 2.) RT, 12 h
4: H2 / 10percent Pd/C / methanol / 2 h / 2068.6 Torr
View Scheme
参考文献
Kuyper, Lee F.; Baccanari, David P.; Jones, Michael L.; Hunter, Robert N.; Tansik, Robert L.; Joyner, Suzanne S.; Boytos, Christine M.; Rudolph, Sharon K.; Knick, Vince; Wilson, H. Robert; Caddell, J. Marc; Friedman, Henry S.; Comley, John C. W.; Stables, Jeremy N.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 4 p. 892 - 903
反应条件
1: Pd(PPh3)2Cl2, Et3N, CuI / dimethylformamide / 48 h / Ambient temperature
2: CuI / dimethylformamide / 4 h / Heating
3: 86 percent / NaNO3, H2SO4 / 1.) 0 deg C, 5 h, 2.) RT, 12 h
4: H2 / 10percent Pd/C / methanol / 2 h / 2068.6 Torr
View Scheme
参考文献
Kuyper, Lee F.; Baccanari, David P.; Jones, Michael L.; Hunter, Robert N.; Tansik, Robert L.; Joyner, Suzanne S.; Boytos, Christine M.; Rudolph, Sharon K.; Knick, Vince; Wilson, H. Robert; Caddell, J. Marc; Friedman, Henry S.; Comley, John C. W.; Stables, Jeremy N.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 4 p. 892 - 903
反应条件
1: CuI / dimethylformamide / 4 h / Heating
2: 86 percent / NaNO3, H2SO4 / 1.) 0 deg C, 5 h, 2.) RT, 12 h
3: H2 / 10percent Pd/C / methanol / 2 h / 2068.6 Torr
View Scheme
参考文献
Kuyper, Lee F.; Baccanari, David P.; Jones, Michael L.; Hunter, Robert N.; Tansik, Robert L.; Joyner, Suzanne S.; Boytos, Christine M.; Rudolph, Sharon K.; Knick, Vince; Wilson, H. Robert; Caddell, J. Marc; Friedman, Henry S.; Comley, John C. W.; Stables, Jeremy N.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 4 p. 892 - 903
