4-氨基-1H-吡唑并[3,4-d]嘧啶-3-甲腈合成路线 （共 11 条）
反应条件
1: 1.) NaH / 1.) DMF, 78 deg C, 2.) 78 deg C, 4 h 2: 37 percent / methanol / 1 h / Ambient temperature 3: 23 percent / H2S gas, NaOCH3 / methanol / 1.) RT, 2.3 h, 2.) 5 deg C, 18 h 4: 48 percent / mercuric(II) chloride, Et3N / dimethylformamide / 3 h / Ambient temperature View Scheme
参考文献
Saxena, Naveen K.; Coleman, Lisa A.; Drach, John C.; Townsend, Leroy B.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 7 p. 1980 - 1983
反应条件
1: 1.) NaH / 1.) DMF, 78 deg C, 2.) 78 deg C, 4 h 2: 37 percent / methanol / 1 h / Ambient temperature View Scheme
参考文献
Saxena, Naveen K.; Coleman, Lisa A.; Drach, John C.; Townsend, Leroy B.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 7 p. 1980 - 1983
反应条件
1: 1.) NaH / 1.) DMF, 78 deg C, 2.) 78 deg C, 4 h 2: 37 percent / methanol / 1 h / Ambient temperature 3: 38 percent / 1.2 N aq. NaOH / 18 h / Ambient temperature View Scheme
参考文献
Saxena, Naveen K.; Coleman, Lisa A.; Drach, John C.; Townsend, Leroy B.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 7 p. 1980 - 1983
反应条件
1: 1.) NaH / 1.) DMF, 78 deg C, 2.) 78 deg C, 4 h 2: 37 percent / methanol / 1 h / Ambient temperature 3: 23 percent / H2S gas, NaOCH3 / methanol / 1.) RT, 2.3 h, 2.) 5 deg C, 18 h View Scheme
参考文献
Saxena, Naveen K.; Coleman, Lisa A.; Drach, John C.; Townsend, Leroy B.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 7 p. 1980 - 1983
反应条件
tris-(dibenzylideneacetone)dipalladium(0); dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in N,N-dimethyl-formamide
T=120°C; 3.5 h; Inert atmosphere;
参考文献
AMGEN INC.
Patent: US2010/331306 A1, 2010 ;
Location in patent: Page/Page column 30 ;
反应条件
ammonium hydroxide
5 h; Heating;
参考文献
Bulychev, Yu. N.; Korbukh, I. A.; Preobrazhenskaya, M. N.; Chernyshov, A. I.; Esipov, S. E.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1984 , vol. 20, # 2 p. 215 - 221
Khimiya Geterotsiklicheskikh Soedinenii, 1984 , vol. 20, # 2 p. 259 - 264
反应条件
1: 51 percent / methanol / 8 h / Heating
2: 83 percent / 20percent aq. NH4OH / 5 h / Heating
View Scheme
参考文献
Bulychev, Yu. N.; Korbukh, I. A.; Preobrazhenskaya, M. N.; Chernyshov, A. I.; Esipov, S. E.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1984 , vol. 20, # 2 p. 215 - 221
Khimiya Geterotsiklicheskikh Soedinenii, 1984 , vol. 20, # 2 p. 259 - 264
反应条件
sodium hydride
1.) DMF, 78 deg C, 2.) 78 deg C, 4 h; Yield given. Multistep reaction;
参考文献
Saxena, Naveen K.; Coleman, Lisa A.; Drach, John C.; Townsend, Leroy B.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 7 p. 1980 - 1983
反应条件
hydrogen sulfide; triethylamine in ethanol
T=20°C; 14 h;
参考文献
Bulychev, Yu. N.; Korbukh, I. A.; Preobrazhenskaya, M. N.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1984 , vol. 20, # 2 p. 210 - 215
Khimiya Geterotsiklicheskikh Soedinenii, 1984 , vol. 20, # 2 p. 253 - 258
反应条件
hydroxylamine hydrochloride; triethylamine in ethanol
2 h; Heating;
参考文献
Bulychev, Yu. N.; Korbukh, I. A.; Preobrazhenskaya, M. N.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1984 , vol. 20, # 2 p. 210 - 215
Khimiya Geterotsiklicheskikh Soedinenii, 1984 , vol. 20, # 2 p. 253 - 258
