2-苯基-1H-咪唑-4-缩醛合成路线 （共 5 条）
反应条件
manganese(IV) dioxide in tetrahydrofuran
参考文献
Warner-Lambert Company
Patent: US4521416 A1, 1985 ;
反应条件
1: 2-phenyl-1H-imidazole-4-carbaldehyde With sodium hydride in N,N-dimethyl-formamide
T=0°C;
2: methyl iodide in N,N-dimethyl-formamide
T=0°C; 3 h;
参考文献
Itoh, Kyosuke; Hayashi, Hideki; Furutachi, Hideki; Matsumoto, Takahiro; Nagatomo, Shigenori; Tosha, Takehiko; Terada, Shoichi; Fujinami, Shuhei; Suzuki, Masatatsu; Kitagawa, Teizo
Journal of the American Chemical Society, 2005 , vol. 127, # 14 p. 5212 - 5223
反应条件
potassium hydroxide; adogen 464 in dichloromethane
T=23°C; 2 h; Yield given;
参考文献
Sircar; Bobowski; Bristol; Weishaar; Evans
Journal of Medicinal Chemistry, 1986 , vol. 29, # 2 p. 261 - 267
反应条件
sodium methylate in N,N-dimethyl-formamide
T=23°C; 6 h; Yield given. Yields of byproduct given;
参考文献
Sircar; Bobowski; Bristol; Weishaar; Evans
Journal of Medicinal Chemistry, 1986 , vol. 29, # 2 p. 261 - 267
反应条件
18-crown-6 ether; potassium carbonate
T=80°C; Methylation; 80 h;
参考文献
Dhainaut, Alain; Tizot, Andre; Raimbaud, Eric; Lockhart, Brian; Lestage, Pierre; Goldstein, Solo
Journal of Medicinal Chemistry, 2000 , vol. 43, # 11 p. 2165 - 2175
