2-丁基-1H-咪唑-4-甲醛合成路线 （共 11 条）
反应条件
oxygen; 2percent V/C in various solvent(s) T=105°C; P=750.075 Torr; 6 h;
参考文献
Guram, Anil; Hagemeyer, Alfred; Lugmair, Claus G.; Turner, Howard W.; Volpe Jr., Anthony F.; Weinberg, W. Henry; Yaccato, Karin
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 2-3 p. 215 - 230
反应条件
1: With hydrogen; triethylamine; palladium 10 on activated carbon in methanol T=20 - 25°C; P=2942.29 - 3677.86 Torr; 8 - 10 h; 2: With hydrogenchloride in water T=25 - 30°C; pH=1.2; 3: With sodium carbonate in water pH=6.8 - 7.5; Product distribution / selectivity;
参考文献
DISHMAN PHARMACEUTICALS AND CHEMICALS LTD; Henk Plum
Patent: US2008/200690 A1, 2008 ;
Location in patent: Page/Page column 4-5 ;
反应条件
sodium hydroxide in water
参考文献
Lonza AG
Patent: US6040457 A1, 2000 ;
反应条件
sodium hydroxide in N-dodecane; water
参考文献
Lonza AG
Patent: US6040457 A1, 2000 ;
反应条件
sodium hydroxide in N-dodecane; water
参考文献
Lonza AG
Patent: US6040457 A1, 2000 ;
反应条件
1: H2O 2: MnO2 / CH2Cl2 View Scheme
参考文献
Journal of Organic Chemistry, , vol. 62, # 24 p. 8449 - 8454
反应条件
1: 72 percent / hydrogen chloride / 18 h / 0 - 15 °C 2: 75 percent / NH3 / 60 °C / high pressure 3: MnO2 / CH2Cl2 View Scheme
参考文献
Journal of Organic Chemistry, , vol. 62, # 24 p. 8449 - 8454
反应条件
N-chloro-succinimide Chlorination;
参考文献
Shilcrat, Susan C.; Mokhallalati, Mohamed K.; Fortunak, Joseph M. D.; Pridgen, Lendon N.
Journal of Organic Chemistry, 1997 , vol. 62, # 24 p. 8449 - 8454
反应条件
N-bromosuccinmide in N,N-dimethyl-formamide T=20°C;
参考文献
Theravance, Inc.
Patent: US2008/269305 A1, 2008 ;
Location in patent: Page/Page column 44 ;
US 20080269305 A1
反应条件
sodium carbonate in N,N-dimethyl-formamide T=100°C; Substitution; 24 h;
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 36, # 9 p. 813 - 815
