(S)-1-(2-氟苯基)乙胺合成路线 （共 13 条）
反应条件
hydrogen; 1,2-benzenedicarboxylic acid; palladium on activated charcoal in methanol T=60°C; P=3750.3 Torr; 12 h;
参考文献
Kanai, Masatomi; Yasumoto, Manabu; Kuriyama, Yokusu; Inomiya, Kenjin; Katsuhara, Yutaka; Higashiyama, Kimio; Ishii, Akihiro
Chemistry Letters, 2004 , vol. 33, # 11 p. 1424 - 1425
反应条件
ammonium formate; palladium on activated charcoal in methanol 0.5 h; Heating; Yields of byproduct given;
参考文献
Bringmann, G.; Geisler, J.-P.
Journal of Fluorine Chemistry, 1990 , vol. 49, # 1 p. 67 - 73
反应条件
1: p-toluenesulfonic acid / toluene / Heating 2: H2 / Raney-nickel W2 / ethanol / 24 h / 3750.3 Torr / Ambient temperature 3: 79 percent / HCO2NH4 / 10percent Pd/C / methanol / 0.5 h / Heating View Scheme
参考文献
Journal of Fluorine Chemistry, , vol. 49, # 1 p. 67 - 73
反应条件
1: H2 / Raney-nickel W2 / ethanol / 24 h / 3750.3 Torr / Ambient temperature 2: 79 percent / HCO2NH4 / 10percent Pd/C / methanol / 0.5 h / Heating View Scheme
参考文献
Journal of Fluorine Chemistry, , vol. 49, # 1 p. 67 - 73
反应条件
1: With N-(2-hydroxybenzyl)amine; C24H34N2O2 in toluene T=110°C; 72 h; 2: With hydrogenchloride in tetrahydrofuran; water T=20°C; 24 h; Overall yield = 65 percent;
参考文献
Organic and Biomolecular Chemistry, , vol. 10, # 45 p. 8960 - 8962,3
Organic and Biomolecular Chemistry, , vol. 10, # 45 p. 8960 - 8962
反应条件
1: 100 percent / ZnCl2 / toluene / 15 h / Heating 2: NaBH4 / methanol / 7 h / 0 °C 3: 99 percent / phthalic acid; H2 / Pd/C / methanol / 12 h / 60 °C / 3750.3 Torr View Scheme
参考文献
Chemistry Letters, , vol. 33, # 11 p. 1424 - 1425
反应条件
1: NaBH4 / methanol / 7 h / 0 °C 2: 99 percent / phthalic acid; H2 / Pd/C / methanol / 12 h / 60 °C / 3750.3 Torr View Scheme
参考文献
Chemistry Letters, , vol. 33, # 11 p. 1424 - 1425
反应条件
2: OH(-), H2O View Scheme
参考文献
Chemical Communications, , # 21 p. 2415 - 2416
反应条件
water; hydroxide Title compound not separated from byproducts;
参考文献
Chemical Communications, , # 21 p. 2415 - 2416
反应条件
1: sodium hydroxide / water; ethyl acetate 2: 5 Pd(II)/C(eggshell); hydrogen / methanol / 24 h / 55 °C / 11251.1 Torr View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 353, # 11-12 p. 2085 - 2092
