phosphoric acid; pyridoxal 5'-phosphate; ω-transaminase from Paracoccus denitrificans; 1-amino-1-phenylethane T=30°C; pH=7.5; 24 h; Enzymatic reaction; Reagent/catalyst; enantioselective reaction;

n-butyllithium; 1,2,2-trichloro-1,1,2-trichloro-ethane 1.) ether, hexane, 25 deg C, 24 h, 2.) ether, hexane, -40 deg C, 1 h; Yield given. Multistep reaction;

1: 86 percent / (NH4)2SO4 / 1.) 100 deg C, 5 h; 125 deg C, 19 h, 2.) TMSCl was added to complete conversion at 25 deg C, then 125 deg C, 12 h 2: 1.) n-BuLi, 2.) hexachloroethane / 1.) ether, hexane, 25 deg C, 24 h, 2.) ether, hexane, -40 deg C, 1 h View Scheme

Yield given. Yields of byproduct given;