(4-甲氧基联苯-4-基)-苯基-甲酮合成路线 （共 22 条）
反应条件
1-ethyl-2-pyrrolidinone; 4-(N,N-dimethlyamino)pyridine; phosphonic acid diethyl ester; nickel dichloride; zinc dibromide in tetrahydrofuran
T=20°C; 3 h;
参考文献
Korn, Tobias J.; Schade, Matthias A.; Cheemala, Murthy N.; Wirth, Stefan; Guevara, Simon A.; Cahiez, Gerard; Knochel, Paul
Synthesis, 2006 , # 21 p. 3547 - 3574
反应条件
SIDip*HCl; palladium diacetate in tetrahydrofuran
T=0°C; Sizuki-Miyaura cross coupling; 2.5 h;
参考文献
Andrus; Song
Organic letters, 2001 , vol. 3, # 23 p. 3761 - 3764
反应条件
1: p-MeOC6H4MnCl With IPr*hydrochloride; bis(acetylacetonate)nickel(II) in tetrahydrofuran
T=0°C; 0.5 h;
2: (4-bromophenyl)(phenyl)methanone in tetrahydrofuran
T=0 - 25°C; 13 h;
参考文献
Leleu, Anne; Fort, Yves; Schneider, Raphael
Advanced Synthesis and Catalysis, 2006 , vol. 348, # 9 p. 1086 - 1092
反应条件
potassium hydroxide in dimethyl sulfoxide
0.75 h;
参考文献
Brousmiche, Darryl W.; Xu, Musheng; Lukeman, Matthew; Wan, Peter
Journal of the American Chemical Society, 2003 , vol. 125, # 42 p. 12961 - 12970
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in toluene
Suzuki coupling; Heating;
参考文献
Xu, Musheng; Lukeman, Matthew; Wan, Peter
Photochemistry and Photobiology, 2006 , vol. 82, # 1 p. 50 - 56
反应条件
1: 1-bromo-4-methoxy-benzene With magnesium in tetrahydrofuran
2: With zinc dibromide in tetrahydrofuran
3: (4-bromophenyl)(phenyl)methanone With 4-(N,N-dimethlyamino)pyridine; phosphonic acid diethyl ester; nickel dichloride in tetrahydrofuran
T=25°C; Negishi cross-coupling; 3 h;
参考文献
Gavryushin, Andrei; Kofink, Christiane; Manolikakes, Georg; Knochel, Paul
Tetrahedron, 2006 , vol. 62, # 32 p. 7521 - 7533
反应条件
1: 4-Fluorobenzophenone; p-MeOC6H4ZnCl With Ni(PCy3)2Cl2 in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=25 - 100°C; 10 h; Schlenk techniqueInert atmosphere;
2: p-MeOC6H4ZnCl in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=100°C; 10 h; Inert atmosphereSchlenk technique;
参考文献
Zhu, Feng; Wang, Zhong-Xia
Journal of Organic Chemistry, 2014 , vol. 79, # 10 p. 4285 - 4292
反应条件
1.1: tetrahydrofuran / 3 h / Heating
1.2: 95 percent / aq. HCl / ethanol / 3 h / Heating
2.1: 92 percent / KOH / dimethylsulfoxide / 0.75 h
View Scheme
参考文献
Brousmiche, Darryl W.; Xu, Musheng; Lukeman, Matthew; Wan, Peter
Journal of the American Chemical Society, 2003 , vol. 125, # 42 p. 12961 - 12970
反应条件
aluminium trichloride; tetrachloroethane, 1,1,2,2-
T=-10°C;
参考文献
Fieser; Bradsher
Journal of the American Chemical Society, 1936 , vol. 58, p. 2337
反应条件
1.1: magnesium / tetrahydrofuran / 3 h / Heating
1.2: trimethyl borate / tetrahydrofuran / -78 - 20 °C
1.3: 90 percent / hydrochloric acid / tetrahydrofuran
2.1: 85 percent / potassium carbonate / Pd(PPh3)4 / toluene / Heating
View Scheme
参考文献
Xu, Musheng; Lukeman, Matthew; Wan, Peter
Photochemistry and Photobiology, 2006 , vol. 82, # 1 p. 50 - 56
