(R)-(-)-2-(苯氨基甲基)吡咯烷合成路线 （共 4 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 11 h;
参考文献
SmithKline Beecham Corporation
Patent: US6403792 B1, 2002 ;
反应条件
1: 1-hydroxybenzotriazole hydrate; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / CH2Cl2 / 20 °C 2: 68 percent / TFA / CH2Cl2 / 2 h / 20 °C 3: 63 percent / lithium aluminum hydride / tetrahydrofuran / 11 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 12 p. 2015 - 2026
反应条件
1: 1-hydroxybenzotriazole hydrate; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / CH2Cl2 / 20 °C 2: 68 percent / TFA / CH2Cl2 / 2 h / 20 °C 3: 63 percent / lithium aluminum hydride / tetrahydrofuran / 11 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 12 p. 2015 - 2026
反应条件
1: 68 percent / TFA / CH2Cl2 / 2 h / 20 °C 2: 63 percent / lithium aluminum hydride / tetrahydrofuran / 11 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 12 p. 2015 - 2026
