反应条件
1: 1.) N-isopropylcyclohexylamine, n-butyllithium / 1.) THF, hexane, -75 deg C, 15 min, 2.) THF, hexane, -78 deg C, 1.5 h 2: 81 percent / 10percent Pd/C, 1,1-diphenylethylene, 1-methylnaphthalene / 3 h / 250 - 260 °C View Scheme
参考文献
Tianjin Taipu Pharmaceutical Science and Technology Development Co., Ltd.
Patent: EP2474522 A1, 2012 ;