4-氨基-N,5-二甲基-1H-吡唑-3-甲酰胺合成路线 （共 5 条）
反应条件
sodium tetrahydroborate; palladium on activated charcoal
参考文献
Manfredini, Stefano; Bazzanini, Rita; Baraldi, Pier Giovanni; Guarneri, Mario; Simoni, Daniele; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 5 p. 917 - 924
反应条件
1: thionyl chloride / 4 h / Reflux
2: diethyl ether; water / 8 h / 0 - 20 °C
3: 0.5 Pd/C; hydrogen / methanol / 24 h / 20 °C / 6080.41 Torr
View Scheme
参考文献
Zhang, Da Qiang; Xu, Gao Fei; Fan, Zhi Jin; Wang, Dao Quan; Yang, Xin Ling; Yuan, De Kai
Chinese Chemical Letters, 2012 , vol. 23, # 6 p. 669 - 672
反应条件
1: diethyl ether; water / 8 h / 0 - 20 °C
2: 0.5 Pd/C; hydrogen / methanol / 24 h / 20 °C / 6080.41 Torr
View Scheme
参考文献
Zhang, Da Qiang; Xu, Gao Fei; Fan, Zhi Jin; Wang, Dao Quan; Yang, Xin Ling; Yuan, De Kai
Chinese Chemical Letters, 2012 , vol. 23, # 6 p. 669 - 672
反应条件
1: sulfuric acid, fuming; nitric acid / 19 h / -5 - 60 °C
2: thionyl chloride / 4 h / Reflux
3: diethyl ether; water / 8 h / 0 - 20 °C
4: 0.5 Pd/C; hydrogen / methanol / 24 h / 20 °C / 6080.41 Torr
View Scheme
参考文献
Zhang, Da Qiang; Xu, Gao Fei; Fan, Zhi Jin; Wang, Dao Quan; Yang, Xin Ling; Yuan, De Kai
Chinese Chemical Letters, 2012 , vol. 23, # 6 p. 669 - 672
反应条件
1.1: water; sodium hydroxide / methanol / 4 h / Reflux
1.2: pH 2 / Acidic conditions
2.1: sulfuric acid, fuming; nitric acid / 19 h / -5 - 60 °C
3.1: thionyl chloride / 4 h / Reflux
4.1: diethyl ether; water / 8 h / 0 - 20 °C
5.1: 0.5 Pd/C; hydrogen / methanol / 24 h / 20 °C / 6080.41 Torr
View Scheme
参考文献
Zhang, Da Qiang; Xu, Gao Fei; Fan, Zhi Jin; Wang, Dao Quan; Yang, Xin Ling; Yuan, De Kai
Chinese Chemical Letters, 2012 , vol. 23, # 6 p. 669 - 672
