1-(4-甲氧基苯基)-1H-1,2,4-三唑合成路线 (共 7 条)
反应条件
hydrogen bromide demethylation, Jones procedure;
参考文献
Foces-Foces; Cabildo; Claramunt; Elguero
Acta Crystallographica Section C: Crystal Structure Communications, 1999 , vol. 55, # 7 p. 1160 - 1163
反应条件
Cu(I) 3-methylsalicylate; potassium carbonate in dimethyl sulfoxide
T=110°C; 3 h;
参考文献
Farahat, Abdelbasset A.; Boykin, David W.
Tetrahedron Letters, 2014 , vol. 55, # 19 p. 3049 - 3051
反应条件
copper(l) iodide; 2-methyl-8-hydroxyquinoline; potassium carbonate in dimethyl sulfoxide
T=90°C; 24 h; Inert atmosphere;
参考文献
Zhang, Yihua; Yang, Xinye; Xing, Hui; Zhang, Ye; Lai, Yisheng; Jiang, Yongwen; Ma, Dawei
Chinese Journal of Chemistry, 2012 , vol. 30, # 4 p. 875 - 880
反应条件
potassium carbonate in di-isopropyl ether; N,N-dimethyl-formamide
参考文献
Janssen Pharmaceutica, N.V.
Patent: US4160841 A1, 1979 ;
反应条件
tetrabutylammonium tetrazolide in acetonitrile
electrosynthesis;
参考文献
Hu, Kai; Niyazymbetov, Murat E.; Evans, Denis H.
Tetrahedron Letters, 1995 , vol. 36, # 39 p. 7027 - 7030
反应条件
T=120°C; 12 h; Inert atmosphere;
参考文献
Romagnoli, Romeo; Baraldi, Pier Giovanni; Cruz-Lopez, Olga; Lopez Cara, Carlota; Carrion, Maria Dora; Brancale, Andrea; Hamel, Ernest; Chen, Longchuan; Bortolozzi, Roberta; Basso, Giuseppe; Viola, Giampietro
Journal of Medicinal Chemistry, 2010 , vol. 53, # 10 p. 4248 - 4258
反应条件
potassium hydroxide in ethanol
Methylation; 12 h; Heating;
参考文献
Woisel, Patrice; Lehaire, Marie-Line; Surpateanu, Gheorghe
Tetrahedron, 2000 , vol. 56, # 3 p. 377 - 380