5-氯-N-苯基苯-1,2-二胺合成路线 （共 18 条）
反应条件
1.1: tetrahydrofuran / 1.5 h / 20 °C 2.1: sodium hydride / tetrahydrofuran; oil / 2 h 2.2: 1 h / 70 °C View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; SIMONEAU, Bruno; DEROY, Patrick; FADER, Lee; FAUCHER, Anne-Marie; GAGNON, Alexandre; GRAND-MAITRE, Chantal; KAWAI, Steven; LANDRY, Serge; MERCIER, Jean-Francois; RANCOURT, Jean
Patent: WO2011/100838 A1, 2011 ;
反应条件
hydrogen in tetrahydrofuran; water
T=120°C; P=37503.8 Torr; 15 h; chemoselective reaction;
参考文献
Jagadeesh, Rajenahally V.; Surkus, Annette-Enrica; Junge, Henrik; Pohl, Marga-Martina; Radnik, Joerg; Rabeah, Jabor; Huan, Heming; Schunemann, Volker; Brueckner, Angelika; Beller, Matthias
Science, 2013 , vol. 342, # 6162 p. 1073 - 1076
反应条件
tri-ruthenium(0)dodecacarbonyl; sodium chloride in acetonitrile
T=220°C; P=37503 Torr; 2 h;
参考文献
Pizzotti, Maddalena; Cenini, Sergio; Quici, Silvio; Tollari, Stefano
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1994 , # 4 p. 913 - 918
反应条件
1: triethylamine / dimethyl sulfoxide / 43 h / 20 °C
2: hydrogenchloride; iron / ethanol; water / 1 h / Reflux
View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; SIMONEAU, Bruno; DEROY, Patrick; FADER, Lee; FAUCHER, Anne-Marie; GAGNON, Alexandre; GRAND-MAITRE, Chantal; KAWAI, Steven; LANDRY, Serge; MERCIER, Jean-Francois; RANCOURT, Jean
Patent: WO2011/100838 A1, 2011 ;
反应条件
1: triethylamine / dimethyl sulfoxide / 43 h / 20 °C
2: hydrogenchloride; iron / ethanol; water / 1 h / Reflux
View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; SIMONEAU, Bruno; DEROY, Patrick; FADER, Lee; FAUCHER, Anne-Marie; GAGNON, Alexandre; GRAND-MAITRE, Chantal; KAWAI, Steven; LANDRY, Serge; MERCIER, Jean-Francois; RANCOURT, Jean
Patent: WO2011/100838 A1, 2011 ;
反应条件
hydrogenchloride; tin(ll) chloride
参考文献
Jacobson; Struebe
Justus Liebigs Annalen der Chemie, 1898 , vol. 303, p. 310
反应条件
hydrogenchloride; methanol
参考文献
Jacobson
Justus Liebigs Annalen der Chemie, 1909 , vol. 367, p. 334 Anm.
参考文献
Jacobson
Justus Liebigs Annalen der Chemie, 1909 , vol. 367, p. 315;
Chem. Zentralbl., 1898 , vol. 69, # II p. 36
参考文献
Jacobson
Justus Liebigs Annalen der Chemie, 1909 , vol. 367, p. 315;
Chem. Zentralbl., 1898 , vol. 69, # II p. 36
反应条件
1: 86 percent / CHCl3 / 20 h / Heating
2: 99.3 percent / EtONa / ethanol / 3 h / Heating
3: 82 percent / K2CO3 / methanol / 12 h / 50 - 55 °C
View Scheme
参考文献
Bianchi; Butti; Rossi; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 4 p. 321 - 326
