5-氯-N-苯基苯-1,2-二胺合成路线 （共 18 条）
反应条件
in tetrahydrofuran
T=20°C; 1.5 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; SIMONEAU, Bruno; DEROY, Patrick; FADER, Lee; FAUCHER, Anne-Marie; GAGNON, Alexandre; GRAND-MAITRE, Chantal; KAWAI, Steven; LANDRY, Serge; MERCIER, Jean-Francois; RANCOURT, Jean
Patent: WO2011/100838 A1, 2011 ;
Location in patent: Page/Page column 26 ;
反应条件
1: 86 percent / CHCl3 / 20 h / Heating
2: 99.3 percent / EtONa / ethanol / 3 h / Heating
3: 34 percent / NaOH / methanol / 5 h / Heating
View Scheme
参考文献
Bianchi; Butti; Rossi; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 4 p. 321 - 326
反应条件
1: 86 percent / CHCl3 / 20 h / Heating
2: 99.3 percent / EtONa / ethanol / 3 h / Heating
3: 79 percent / K2CO3 / methanol / 12 h / 50 - 55 °C
View Scheme
参考文献
Bianchi; Butti; Rossi; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 4 p. 321 - 326
反应条件
1: 86 percent / CHCl3 / 20 h / Heating
2: 99.3 percent / EtONa / ethanol / 3 h / Heating
3: 1.) 50 percent NaH / 1.) DMF, 60 - 70 deg C, 30 min; 2.) DMF, 60 - 70 deg C, 10 h
View Scheme
参考文献
Bianchi; Butti; Rossi; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 4 p. 321 - 326
反应条件
1: 86 percent / CHCl3 / 20 h / Heating
2: 99.3 percent / EtONa / ethanol / 3 h / Heating
3: 34 percent / NaOH / methanol / 5 h / Heating
4: 73 percent / 2 N aq. NaOH / ethanol / 0.5 h / 50 °C
View Scheme
参考文献
Bianchi; Butti; Rossi; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 4 p. 321 - 326
反应条件
1: 86 percent / CHCl3 / 20 h / Heating
2: 99.3 percent / EtONa / ethanol / 3 h / Heating
3: 57 percent / NaOH / methanol / 10 h / Ambient temperature
4: 81 percent / H2S / pyridine; triethylamine / 3 h
View Scheme
参考文献
Bianchi; Butti; Rossi; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 4 p. 321 - 326
反应条件
1: 86 percent / CHCl3 / 20 h / Heating
2: 99.3 percent / EtONa / ethanol / 3 h / Heating
3: 82 percent / K2CO3 / methanol / 12 h / 50 - 55 °C
4: 38.5 percent / P2S5 / xylene / 8 h / Heating
View Scheme
参考文献
Bianchi; Butti; Rossi; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 4 p. 321 - 326
反应条件
1: 86 percent / CHCl3 / 20 h / Heating
2: 99.3 percent / EtONa / ethanol / 3 h / Heating
View Scheme
参考文献
Bianchi; Butti; Rossi; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 4 p. 321 - 326
