(R)-1-(+)-2-哌啶乙醇合成路线 （共 11 条）
反应条件
1: With lithium aluminium tetrahydride in diethyl ether Heating; 2: With hydrogen; palladium on activated charcoal in methanol Further stages.;
参考文献
Yamazaki; Dokoshi; Kibayashi
Organic letters, 2001 , vol. 3, # 2 p. 193 - 196
反应条件
1.1: 69 percent / AcCl / toluene / Heating 2.1: Vitride / toluene / -78 °C 2.2: 60 percent / HCl 3.1: TiCl4 / toluene / 50 °C 4.1: K2CO3 / acetone 5.1: OsO4; NaIO4 / dioxane; H2O 6.1: LiAlH4 / diethyl ether / Heating 6.2: 52 percent / H2 / Pd-C / methanol View Scheme
参考文献
Organic letters, , vol. 3, # 2 p. 193 - 196
反应条件
1.1: TiCl4 / toluene / 50 °C 2.1: K2CO3 / acetone 3.1: OsO4; NaIO4 / dioxane; H2O 4.1: LiAlH4 / diethyl ether / Heating 4.2: 52 percent / H2 / Pd-C / methanol View Scheme
参考文献
Organic letters, , vol. 3, # 2 p. 193 - 196
反应条件
1.1: Vitride / toluene / -78 °C 1.2: 60 percent / HCl 2.1: TiCl4 / toluene / 50 °C 3.1: K2CO3 / acetone 4.1: OsO4; NaIO4 / dioxane; H2O 5.1: LiAlH4 / diethyl ether / Heating 5.2: 52 percent / H2 / Pd-C / methanol View Scheme
参考文献
Organic letters, , vol. 3, # 2 p. 193 - 196
反应条件
1.1: K2CO3 / acetone 2.1: OsO4; NaIO4 / dioxane; H2O 3.1: LiAlH4 / diethyl ether / Heating 3.2: 52 percent / H2 / Pd-C / methanol View Scheme
参考文献
Organic letters, , vol. 3, # 2 p. 193 - 196
反应条件
1: With (+)-10-camphorsulfonic acid in ethanol Heating; 2: With potassium hydroxide 0.25 h; Heating; Further stages.;
参考文献
Snider, Barry B.; Grabowski, James F.
Journal of Organic Chemistry, 2007 , vol. 72, # 3 p. 1039 - 1042
反应条件
2-(2,4,6-trimethyl-phenyl)-2,5,6,7-tetrahydro-pyrrolo[2,1-c] [1,2,4]triazol-4-ylium perchlorate; (4aR,9aS)-6-bromo-4-hydroxy-4,4a,9,9a-tetrahydroindeno[2,1-b][1,4]oxazin-3(2H)-one; potassium carbonate in isopropanol acetate T=23°C; 24 h; Resolution of racemate;
参考文献
Chemical Communications, , vol. 48, # 71 p. 8892 - 8894
反应条件
Resolution of racemateIndustrial scale;
参考文献
Zanka, Atsuhiko; Uematsu, Ryoichi; Morinaga, Yasuhiro; Yasuda, Hironobu; Yamazaki, Hiroshi
Organic Process Research and Development, 1999 , vol. 3, # 6 p. 389 - 393
反应条件
1: NaOH / dioxane; H2O 2: PDC / dimethylformamide View Scheme
参考文献
Yamazaki; Dokoshi; Kibayashi
Organic letters, 2001 , vol. 3, # 2 p. 193 - 196
反应条件
sodium hydroxide in 1,4-dioxane; water
参考文献
Yamazaki; Dokoshi; Kibayashi
Organic letters, 2001 , vol. 3, # 2 p. 193 - 196
