2-乙炔基-4,6-二氟苯胺合成路线 （共 6 条）
反应条件
Li2CuCl4 in ethanol T=20°C; 16 h;
参考文献
Arcadi, Antonio; Bianchi, Gabriele; Marinelli, Fabio
Synthesis, 2004 , # 4 p. 610 - 618
反应条件
potassium hydroxide in benzene
0.666667 h;
参考文献
Politanskaya, Larisa V.; Chuikov, Igor P.; Kolodina, Ekaterina A.; Shvartsberg, Mark S.; Shteingarts, Vitalij D.
Journal of Fluorine Chemistry, 2012 , vol. 135, p. 97 - 107
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
T=20°C;
参考文献
Arcadi, Antonio; Bianchi, Gabriele; Marinelli, Fabio
Synthesis, 2004 , # 4 p. 610 - 618
反应条件
1: 91 percent / Et3N / PdCl2(PPh3)2; CuI / dimethylformamide / 50 °C
2: 70 percent / TBAF / tetrahydrofuran / 20 °C
View Scheme
参考文献
Arcadi, Antonio; Bianchi, Gabriele; Marinelli, Fabio
Synthesis, 2004 , # 4 p. 610 - 618
反应条件
1: copper(l) iodide; Pd2(PPh3)2Cl2; sodium acetate; triethylamine / 3 h / 70 °C / Inert atmosphere
2: potassium hydroxide / benzene / 0.67 h
View Scheme
参考文献
Politanskaya, Larisa V.; Chuikov, Igor P.; Kolodina, Ekaterina A.; Shvartsberg, Mark S.; Shteingarts, Vitalij D.
Journal of Fluorine Chemistry, 2012 , vol. 135, p. 97 - 107
反应条件
1: iodine; iodic acid / 1,4-dioxane; water / 3 h / Reflux
2: copper(l) iodide; Pd2(PPh3)2Cl2; sodium acetate; triethylamine / 3 h / 70 °C / Inert atmosphere
3: potassium hydroxide / benzene / 0.67 h
View Scheme
参考文献
Politanskaya, Larisa V.; Chuikov, Igor P.; Kolodina, Ekaterina A.; Shvartsberg, Mark S.; Shteingarts, Vitalij D.
Journal of Fluorine Chemistry, 2012 , vol. 135, p. 97 - 107
