甲基-4-(吗啉代甲基)-苯酸酯合成路线 （共 5 条）
反应条件
sodium tetrahydroborate; acetic acid in chloroform T=0 - 20°C; 13 h;
参考文献
Koroleva, Elena V.; Kadutskii, Aleksey P.; Farina, Alexander V.; Ignatovich, Janna V.; Ermolinskaya, Anastasiya L.; Gusak, Klaudiya N.; Kalinichenko, Elena N.
Tetrahedron Letters, 2012 , vol. 53, # 38 p. 5056 - 5058
反应条件
in tetrahydrofuran 48 h; Ambient temperature; Yield given;
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 2 p. 234 - 240
反应条件
1: morpholine With formic acid 0.25 h; cooling; 2: 4-formylbenzoic acid methyl ester T=180 - 200°C; Leuckart-Wallach reaction; 8 h; Further stages.;
参考文献
Ignatovich; Gusak; Chernikhova; Kozlov; Koroleva
Chemistry of Heterocyclic Compounds, 2007 , vol. 43, # 12 p. 1540 - 1543
反应条件
hydrogenchloride in water Reflux;
参考文献
Koroleva; Gusak; Ermolinskaya; Ignatovich
Russian Journal of Organic Chemistry, 2013 , vol. 49, # 4 p. 563 - 567
Zh. Org. Khim., 2013 , vol. 49, # 4 p. 580 - 584
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=20°C; 2 h;
参考文献
JANSSEN PHARMACEUTICA N.V.; ADDEX PHARMACEUTICALS S.A.
Patent: WO2007/104783 A2, 2007 ;
Location in patent: Page/Page column 48 ;
WO 2007/104783 A2
