2-氟-3-甲基丁-2-烯酸乙酯合成路线 （共 6 条）
反应条件
1: (diethoxy-phosphoryl)-fluoro-acetic acid ethyl ester With sodium hydride in ethylene glycol dimethyl ether
T=0 - 20°C; 0.333333 h;
2: acetone in metthoxyethane
Heating / reflux;
参考文献
Chen, Li; Ding, Qingjie; Liu, Jin-Jun; Yang, Song; Zhang, Zhuming
Patent: US2007/213341 A1, 2007 ;
Location in patent: Page/Page column 89-90 ;
反应条件
(i) NaH, Et2O, (ii) /BRN= 635680/; Multistep reaction;
参考文献
Machleidt,H.; Wessendorf,R.
Justus Liebigs Annalen der Chemie, 1964 , vol. 674, p. 1 - 10
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran
T=20°C; Julia-Kocienski reaction; 12 h;
参考文献
Calata, Charlene; Catel, Jean-Marie; Pfund, Emmanuel; Lequeux, Thierry
Tetrahedron, 2009 , vol. 65, # 20 p. 3967 - 3973
反应条件
(diethylamido)sulfur trifluoride
T=25°C; 3 h;
参考文献
Parisi; Gattuso; Notti; Raymo; Abeles
Journal of Organic Chemistry, 1995 , vol. 60, # 16 p. 5174 - 5179
反应条件
in tetrahydrofuran; diethyl ether; hexane; toluene
T=-78 - 20°C; 6 h; Yield given;
参考文献
Tsai, Hou-Jen; Thenappan, Alagappan; Burton, Donald J.
Phosphorus, Sulfur and Silicon and the Related Elements, 1995 , vol. 105, # 1-4 p. 205 - 212
参考文献
Sterlin et al.
Khimicheskaya Nauka i Promyshlennost, 1958 , vol. 3, p. 540
Chem.Abstr., 1959 , p. 4195
