N-丁基-2-氯-5-硝基苯甲酰胺合成路线 （共 6 条）
反应条件
1.1: sodium hydride / 1,4-dioxane; mineral oil / 2 h / 70 °C / Cooling with ice; Inert atmosphere 1.2: 4 h / 70 °C / Inert atmosphere 2.1: sodium tetrahydroborate; palladium 10 on activated carbon / methanol; water / 20 °C / Inert atmosphere View Scheme
参考文献
Fiorino, Ferdinando; Eiden, Martin; Giese, Armin; Severino, Beatrice; Esposito, Antonella; Groschup, Martin H.; Perissutti, Elisa; Magli, Elisa; Incisivo, Giuseppina Maria; Ciano, Antonio; Frecentese, Francesco; Kretzschmar, Hans A.; Wagner, Jens; Santagada, Vincenzo; Caliendo, Giuseppe
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 16 p. 5001 - 5011
反应条件
triethylamine in N,N-dimethyl-formamide
T=0 - 20°C;
参考文献
Fiorino, Ferdinando; Eiden, Martin; Giese, Armin; Severino, Beatrice; Esposito, Antonella; Groschup, Martin H.; Perissutti, Elisa; Magli, Elisa; Incisivo, Giuseppina Maria; Ciano, Antonio; Frecentese, Francesco; Kretzschmar, Hans A.; Wagner, Jens; Santagada, Vincenzo; Caliendo, Giuseppe
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 16 p. 5001 - 5011
反应条件
1: 2-carboxy-4-nitro-chlorobenzene With benzotriazol-1-ol; dicyclohexyl-carbodiimide in N,N-dimethyl-formamide
T=0°C; 0.5 h;
2: N-butylamine in N,N-dimethyl-formamide
T=0 - 20°C;
参考文献
Cardoso; Bicalho; Genari; Santagada; Caliendo; Perissutti; Donato; De Nucci
European Journal of Medicinal Chemistry, 2006 , vol. 41, # 3 p. 408 - 416
反应条件
sodium hydrogencarbonate in dichloromethane; water
Ambient temperature;
参考文献
Shinde; Shenoy; Pai
Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1990 , vol. 29, # 8 p. 711 - 720
反应条件
1: SOCl2 / 3 h / Heating
2: 83 percent / NaHCO3 / CH2Cl2; H2O / Ambient temperature
View Scheme
参考文献
Shinde; Shenoy; Pai
Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1990 , vol. 29, # 8 p. 711 - 720
反应条件
sodium hydroxide; tetrabutylammomium bromide in toluene
T=40°C; 0.5 h; other catalysts, other NaOH concentrations, other solvents and reaction time; Product distribution;
参考文献
Nisato, Dino; Frigerio, Marco; Boccardi, Giovanni; Palmisano, Giovanni
Synthesis, 1982 , # 12 p. 1081 - 1083
