4-氯-5-氟-1-[三(1-甲基乙基)硅基]-1H-吡咯并[2,3-b]吡啶合成路线 （共 5 条）
反应条件
1: With sec.-butyllithium in tetrahydrofuran; cyclohexane T=-78°C; 0.5 h; 2: With N-fluoro-N-(phenylsulfonyl)benzene-sulfonamide in tetrahydrofuran; cyclohexane T=-78°C; 0.416667 h; Further stages.;
参考文献
L'Heureux, Alexandre; Thibault, Carl; Ruel, Rejean
Tetrahedron Letters, 2004 , vol. 45, # 11 p. 2317 - 2319
反应条件
1.1: sodium hydride / tetrahydrofuran; hexane / 0.25 h / 0 °C 1.2: 93.5 percent / tetrahydrofuran; hexane / 18 h / 80 °C 2.1: sec-butyllithium / tetrahydrofuran; cyclohexane / 0.5 h / -78 °C 2.2: 66 percent / N-fluorobenzenesulfonimide / tetrahydrofuran; cyclohexane / 0.42 h / -78 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 45, # 11 p. 2317 - 2319
反应条件
1.1: sodium hydride / tetrahydrofuran; hexane / 0.25 h / 0 °C 1.2: 93.5 percent / tetrahydrofuran; hexane / 18 h / 80 °C 2.1: sec-butyllithium / tetrahydrofuran; cyclohexane / 0.5 h / -78 °C 2.2: 66 percent / N-fluorobenzenesulfonimide / tetrahydrofuran; cyclohexane / 0.42 h / -78 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 45, # 11 p. 2317 - 2319
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
T=20°C; 1 h;
参考文献
ASTELLAS PHARMA INC.
Patent: WO2007/7919 A2, 2007 ;
Location in patent: Page/Page column 43 ;
WO 2007/007919 A2
反应条件
sodium iodide in acetonitrile
T=150°C; 0.25 h; Microwave irradiation;
参考文献
DHANAK, Dashyant; Newlander, Kenneth Allen
Patent: US2007/149561 A1, 2007 ;
Location in patent: Page/Page column 85 ;
US 20070149561 A1
