1: 2,6-di-fluoro-pyridine With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-75°C; 1.5 h; 2: chloro-trimethyl-silane in tetrahydrofuran; hexane T=-75 - 20°C;

lithium diisopropyl amide in tetrahydrofuran; hexane

1: 3 percent / lithium diisopropylamide / tetrahydrofuran; hexane / 0.5 h / -75 °C 2: 95 percent / lithium diisopropylamide / tetrahydrofuran; hexane View Scheme