4'-甲氧基-3',5-二-2-丙烯基-(1,1'-联苯)-2-醇合成路线 （共 17 条）
反应条件
1: With boron tribromide in dichloromethane T=-78°C; 2: With water
参考文献
Chemistry and Biology, , vol. 18, # 8 p. 1053 - 1064
反应条件
1: 10 palladium on activated charcoal; hydrogen 2: boron tribromide / dichloromethane / -78 °C View Scheme
参考文献
Schuehly, Wolfgang; Paredes, Juan Manuel Viveros; Kleyer, Jonas; Huefner, Antje; Anavi-Goffer, Sharon; Raduner, Stefan; Altmann, Karl-Heinz; Gertsch, Juerg
Chemistry and Biology, 2011 , vol. 18, # 8 p. 1053 - 1064
反应条件
1: 2-allyl-4-bromoanisole With magnesium; ethylene dibromide in diethyl ether
1 h; Reflux;
2: 1-allyl-4-oxocyclohexa-2,5-dienylethanoate in diethyl ether
T=0°C; 0.5 h;
参考文献
Denton, Ross M.; Scragg, James T.; Saska, Jan
Tetrahedron Letters, 2011 , vol. 52, # 20 p. 2554 - 2556
反应条件
palladium diacetate; potassium carbonate; dicyclohexyl(2',6'-diisopropoxy-[1,1'-biphenyl]-2-yl)phosphine in ethylene glycol dimethyl ether; water
T=130°C; Suzuki-Miyaura coupling; 0.166667 h; Microwave irradiation;
参考文献
Kwak, Jae-Hwan; Cho, Young Ae; Jang, Jae-Yong; Seo, Seung-Yong; Lee, Heesoon; Hong, Jin Tae; Han, Sang-Bae; Lee, Kiho; Kwak, Young-Shin; Jung, Jae-Kyung
Tetrahedron, 2011 , vol. 67, # 48 p. 9401 - 9404
反应条件
tetrakis(triphenylphosphine) palladium(0); caesium carbonate in ethylene glycol dimethyl ether; water
Suzuki coupling; RefluxInert atmosphere;
参考文献
Lin, Jyh Ming; Prakasha Gowda; Sharma, Arun K.; Amin, Shantu
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 10 p. 3202 - 3211
反应条件
1.1: BCl3·DMS / trans-1,2-dichloroethylene; dichloromethane / 18 h / Reflux
2.1: acetic acid / 8 h
3.1: magnesium; ethylene dibromide / diethyl ether / 1 h / Reflux
3.2: 0.5 h / 0 °C
View Scheme
参考文献
Denton, Ross M.; Scragg, James T.; Saska, Jan
Tetrahedron Letters, 2011 , vol. 52, # 20 p. 2554 - 2556
反应条件
1.1: acetic acid / 8 h
2.1: magnesium; ethylene dibromide / diethyl ether / 1 h / Reflux
2.2: 0.5 h / 0 °C
View Scheme
参考文献
Denton, Ross M.; Scragg, James T.; Saska, Jan
Tetrahedron Letters, 2011 , vol. 52, # 20 p. 2554 - 2556
反应条件
trifluoroacetic acid in benzene
10 h; Ambient temperature;
参考文献
Fukuyama, Yoshiyasu; Otoshi, Yukio; Miyoshi, Kumi; Nakamura, Kazuhiko; Kodama, Mitsuaki; et al.
Tetrahedron, 1992 , vol. 48, # 3 p. 377 - 392
反应条件
1.1: (COBr)2; triphenyl-phosphine oxide / chloroform / 7 h
2.1: [2,2']bipyridinyl; copper(l) iodide / benzene / 5 - 20 °C
3.1: magnesium; ethylene dibromide / diethyl ether / 1 h / Reflux
3.2: 0.5 h / 0 °C
View Scheme
参考文献
Denton, Ross M.; Scragg, James T.; Saska, Jan
Tetrahedron Letters, 2011 , vol. 52, # 20 p. 2554 - 2556
反应条件
1.1: [2,2']bipyridinyl; copper(l) iodide / benzene / 5 - 20 °C
2.1: magnesium; ethylene dibromide / diethyl ether / 1 h / Reflux
2.2: 0.5 h / 0 °C
View Scheme
参考文献
Denton, Ross M.; Scragg, James T.; Saska, Jan
Tetrahedron Letters, 2011 , vol. 52, # 20 p. 2554 - 2556
