1: Honokiol With potassium carbonate in N,N-dimethyl-formamide T=20 - 25°C; Williamson synthesis; 2: methyl iodide in N,N-dimethyl-formamide T=30°C; Williamson synthesis; 6 h;

1.1: potassium carbonate / acetone / 0.5 h 1.2: 4 h / 20 °C 2.1: n-butyllithium; tri-isopropoxy-borane / tetrahydrofuran; hexane / 2 h / -78 - 20 °C 2.2: 0.5 h / 20 °C 3.1: palladium diacetate; potassium carbonate; dicyclohexyl(2',6'-diisopropoxy-[1,1'-biphenyl]-2-yl)phosphine / ethylene glycol dimethyl ether; water / 0.17 h / 130 °C / Microwave irradiation View Scheme

1.1: n-butyllithium; tri-isopropoxy-borane / tetrahydrofuran; hexane / 2 h / -78 - 20 °C 1.2: 0.5 h / 20 °C 2.1: palladium diacetate; potassium carbonate; dicyclohexyl(2',6'-diisopropoxy-[1,1'-biphenyl]-2-yl)phosphine / ethylene glycol dimethyl ether; water / 0.17 h / 130 °C / Microwave irradiation View Scheme

in methanol

1.1: Reflux 2.1: potassium carbonate / acetone / 0.25 h / Inert atmosphere 2.2: 1.5 h / Reflux 3.1: n-butyllithium / tetrahydrofuran / 0.83 h / -78 °C / Inert atmosphere 3.2: 2 h / -78 - 20 °C 4.1: hydrogenchloride; water / tetrahydrofuran 5.1: tetrakis(triphenylphosphine) palladium(0); caesium carbonate / ethylene glycol dimethyl ether; water / Reflux; Inert atmosphere View Scheme

1: Methylhonokiol With potassium carbonate in N,N-dimethyl-formamide T=20°C; 0.5 h; 2: methyl iodide in N,N-dimethyl-formamide T=20°C; 3 h;

1.1: boron tribromide / dichloromethane / -78 °C 2.1: potassium hydroxide 2.2: Microwave irradiation View Scheme