3-(2-吡啶基硫基)丙酸合成路线 （共 10 条）
反应条件
in methanol T=20°C; 3 h;
参考文献
WO2005/112919 A2, ;
Page/Page column 151 ;
反应条件
triethylamine in dichloromethane T=0 - 20°C; Substitution; 0.833333 h;
参考文献
Synthetic Communications, , vol. 28, # 17 p. 3213 - 3217
反应条件
acetic acid in ethanol 12 h; Ambient temperature;
参考文献
Journal of the American Chemical Society, , vol. 120, # 46 p. 12108 - 12116
反应条件
triethylamine; trifluoroacetic acid; trifluoroacetic anhydride in methanol; dichloromethane; dimethyl sulfoxide
反应条件
sodium hydroxide; chlorine; sodium hydrogencarbonate in dichloromethane; water
反应条件
1: SO2Cl2 / CH2Cl2 / 1 h / 20 °C 2: 77 percent / triethylamine / CH2Cl2 / 0.83 h / 0 - 20 °C View Scheme
参考文献
Synthetic Communications, , vol. 28, # 17 p. 3213 - 3217
反应条件
boron trifluoride diethyl etherate in ethyl acetate T=20°C;
参考文献
Journal of Medicinal Chemistry, , vol. 53, # 13 p. 4877 - 4890
反应条件
dicyclohexyl-carbodiimide in tetrahydrofuran 0 deg C, 1 h, then 20 deg C, 2 h;
参考文献
Shval'e, A. F.; Ofitserov, V. I.; Samukov, V. V.
J. Gen. Chem. USSR (Engl. Transl.), 1985 , vol. 55, # 9 p. 2152,1909 - 1910
反应条件
triethylamine in tetrahydrofuran; dichloromethane; trifluoroacetic acid; isobutyl chloroformate
参考文献
NeoRx Corporation
Patent: US5608060 A1, 1997 ;
