2-甲基-4,6-二氯烟酸乙酯合成路线 （共 3 条）
反应条件
N-benzyl-N,N,N-triethylammonium chloride; trichlorophosphate in acetonitrile T=20°C; Inert atmosphereReflux;
参考文献
Journal of Medicinal Chemistry, , vol. 52, # 23 p. 7473 - 7487
反应条件
1.1: 2,4,6-Trichlorophenol; trichlorophosphate / 3 h / 100 °C 1.2: 1.5 h / 155 °C 2.1: trichlorophosphate / 2.5 h / 140 °C View Scheme
反应条件
tetra(n-butyl)ammonium hydroxide; water T=85°C; 5 h;
参考文献
NEUROGEN CORPORATION
Patent: WO2004/43925 A2, 2004 ;
Location in patent: Page 122-123 ;
