1H-咪唑并[4,5-B]吡啶 4-氧化物合成路线 (共 6 条)
反应条件
1: 67 percent / trifluoroacetic acid; HNO3 / 3 h / 90 °C 2: 80 percent / POCl3 / dimethylformamide / 2 h / Heating View Scheme
参考文献
GLAXOSMITHKLINE LLC; RIVERO, Ralph, A.; TEDESCO, Rosanna
Patent: WO2013/95761 A1, 2013 ;
反应条件
trichlorophosphate T=100°C; 6 h;
参考文献
Middleton; Wibberley
Journal of Heterocyclic Chemistry, 1980 , vol. 17, # 8 p. 1757 - 1760
反应条件
trichlorophosphate 2 h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Itoh; Ono; Sugawara; Mizuno
Journal of Heterocyclic Chemistry, 1982 , vol. 19, # 3 p. 513 - 517
反应条件
trichlorophosphate T=20 - 90°C; 18 h;
参考文献
Tedder, Martina E.; Nie, Zhe; Margosiak, Stephen; Chu, Shaosong; Feher, Victoria A.; Almassy, Robert; Appelt, Krzysztof; Yager, Kraig M.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 12 p. 3165 - 3168
反应条件
trichlorophosphate 2 h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Itoh; Ono; Sugawara; Mizuno
Journal of Heterocyclic Chemistry, 1982 , vol. 19, # 3 p. 513 - 517
反应条件
nitric acid in trifluoroacetic acid T=90°C; 3 h;
参考文献
Antonini; Cristalli; Franchetti; Grifantini; Martelli; Petrelli
Journal of Pharmaceutical Sciences, 1984 , vol. 73, # 3 p. 366 - 369