1-氧代-2,3-二氢-1H-茚-5-羧酸甲酯合成路线 （共 9 条）
反应条件
1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine in N,N-dimethyl-formamide
T=70°C; P=2585.81 Torr; 48 h;
参考文献
MERCK SHARP and DOHME CORP.; ANDRESEN, Brian, M.; ANTHONY, Neville, J.; MILLER, Thomas, A.
Patent: WO2014/74422 A1, 2014 ;
Location in patent: Paragraph 00201 ;
反应条件
1: 1-oxo-indan-5-carboxylic acid amide With hydrogenchloride in water
T=90°C; 2 h;
2: diazomethyl-trimethyl-silane in methanol; diethyl ether
参考文献
Irm LLC
Patent: US2009/75996 A1, 2009 ;
Location in patent: Page/Page column 21 ;
反应条件
chromium(VI) oxide in water; acetic acid
T=20°C; 12 h;
参考文献
Matveeva; Podrugina; Zefirova; Alekseev; Bachurin; Pellicciari; Zefirov
Russian Journal of Organic Chemistry, 2002 , vol. 38, # 12 p. 1764 - 1768
反应条件
1: SOCl2 / benzene / 2 h / Heating
2: methanol / 3 h / 0 °C
3: 20 percent / CrO3 / acetic acid; H2O; acetic acid / 12 h / 20 °C
View Scheme
参考文献
Matveeva; Podrugina; Zefirova; Alekseev; Bachurin; Pellicciari; Zefirov
Russian Journal of Organic Chemistry, 2002 , vol. 38, # 12 p. 1764 - 1768
反应条件
1: 98 percent / aluminium chloride / benzene / 4 h / 20 °C
2: 95 percent / Br2; KOH / H2O / 3 h / 55 °C
3: SOCl2 / benzene / 2 h / Heating
4: methanol / 3 h / 0 °C
5: 20 percent / CrO3 / acetic acid; H2O; acetic acid / 12 h / 20 °C
View Scheme
参考文献
Matveeva; Podrugina; Zefirova; Alekseev; Bachurin; Pellicciari; Zefirov
Russian Journal of Organic Chemistry, 2002 , vol. 38, # 12 p. 1764 - 1768
反应条件
1: 95 percent / Br2; KOH / H2O / 3 h / 55 °C
2: SOCl2 / benzene / 2 h / Heating
3: methanol / 3 h / 0 °C
4: 20 percent / CrO3 / acetic acid; H2O; acetic acid / 12 h / 20 °C
View Scheme
参考文献
Matveeva; Podrugina; Zefirova; Alekseev; Bachurin; Pellicciari; Zefirov
Russian Journal of Organic Chemistry, 2002 , vol. 38, # 12 p. 1764 - 1768
反应条件
1: methanol / 3 h / 0 °C
2: 20 percent / CrO3 / acetic acid; H2O; acetic acid / 12 h / 20 °C
View Scheme
参考文献
Matveeva; Podrugina; Zefirova; Alekseev; Bachurin; Pellicciari; Zefirov
Russian Journal of Organic Chemistry, 2002 , vol. 38, # 12 p. 1764 - 1768
参考文献
Aono,T. et al.
Chemical and Pharmaceutical Bulletin, 1978 , vol. 26, p. 2475 - 2482
反应条件
1) DMF, reflux, 10 min; Multistep reaction. Yields of byproduct given;
参考文献
Garland; Miyano; Pireh; Clare; Finnegan; Swenton
Journal of Organic Chemistry, 1990 , vol. 55, # 23 p. 5854 - 5861
