甲基 5-氨基-1H-吲哚-3-羧酸合成路线 （共 4 条）
反应条件
5 palladium on charcoal; hydrogen in ethanol
P=760.051 Torr; 2 h;
参考文献
Castellano, Sabrina; Spannhoff, Astrid; Milite, Ciro; Dal Piaz, Fabrizio; Cheng, Donghang; Tosco, Alessandra; Viviano, Monica; Yamani, Abdellah; Cianciulli, Agostino; Sala, Marina; Cura, Vincent; Cavarelli, Jean; Novellino, Ettore; Mai, Antonello; Bedford, Mark T.; Sbardella, Gianluca
Journal of Medicinal Chemistry, 2012 , vol. 55, # 22 p. 9875 - 9890
反应条件
1: sulfuric acid / 6 h / |Reflux
2: 5 palladium on charcoal; hydrogen / ethanol / 2 h / 760.05 Torr
View Scheme
参考文献
Castellano, Sabrina; Spannhoff, Astrid; Milite, Ciro; Dal Piaz, Fabrizio; Cheng, Donghang; Tosco, Alessandra; Viviano, Monica; Yamani, Abdellah; Cianciulli, Agostino; Sala, Marina; Cura, Vincent; Cavarelli, Jean; Novellino, Ettore; Mai, Antonello; Bedford, Mark T.; Sbardella, Gianluca
Journal of Medicinal Chemistry, 2012 , vol. 55, # 22 p. 9875 - 9890
反应条件
1.1: oxalyl dichloride / diethyl ether / 0 - 20 °C / |Inert atmosphere
1.2: 2 h / |Reflux; |Inert atmosphere
2.1: dihydrogen peroxide / water / 4 h / |Reflux
3.1: sulfuric acid / 6 h / |Reflux
4.1: 5 palladium on charcoal; hydrogen / ethanol / 2 h / 760.05 Torr
View Scheme
参考文献
Castellano, Sabrina; Spannhoff, Astrid; Milite, Ciro; Dal Piaz, Fabrizio; Cheng, Donghang; Tosco, Alessandra; Viviano, Monica; Yamani, Abdellah; Cianciulli, Agostino; Sala, Marina; Cura, Vincent; Cavarelli, Jean; Novellino, Ettore; Mai, Antonello; Bedford, Mark T.; Sbardella, Gianluca
Journal of Medicinal Chemistry, 2012 , vol. 55, # 22 p. 9875 - 9890
反应条件
1: dihydrogen peroxide / water / 4 h / |Reflux
2: sulfuric acid / 6 h / |Reflux
3: 5 palladium on charcoal; hydrogen / ethanol / 2 h / 760.05 Torr
View Scheme
参考文献
Castellano, Sabrina; Spannhoff, Astrid; Milite, Ciro; Dal Piaz, Fabrizio; Cheng, Donghang; Tosco, Alessandra; Viviano, Monica; Yamani, Abdellah; Cianciulli, Agostino; Sala, Marina; Cura, Vincent; Cavarelli, Jean; Novellino, Ettore; Mai, Antonello; Bedford, Mark T.; Sbardella, Gianluca
Journal of Medicinal Chemistry, 2012 , vol. 55, # 22 p. 9875 - 9890
