(3S,4S)-3-己基-4-[(S)-2-羟基十三烷基]-2-氧杂环丁酮合成路线 （共 120 条）
反应条件
hydrogen; palladium dihydroxide in ethyl acetate 12 h;
参考文献
Yadav; Reddy, M. Sridhar; Prasad
Tetrahedron Letters, 2006 , vol. 47, # 29 p. 4995 - 4998
反应条件
hydrogen fluoride; water in acetonitrile T=20°C;
参考文献
Chongqing Zhien Pharmaceutical Co., Ltd.; Sichuan University
Patent: EP2280007 A1, 2011 ;
Location in patent: Page/Page column 11-12 ;
反应条件
pyridine hydrogenfluoride in tetrahydrofuran T=0 - 20°C; 12 h; Inert atmosphere;
参考文献
Venukadasula, Phanindra K. M.; Chegondi, Rambabu; Maitra, Soma; Hanson, Paul R.
Organic Letters, 2010 , vol. 12, # 7 p. 1556 - 1559
反应条件
pyridinium p-toluenesulfonate in ethanol T=50 - 55°C; 2 h;
参考文献
Barbier, Pierre; Schneider, Fernand
Journal of Organic Chemistry, 1988 , vol. 53, # 6 p. 1218 - 1221
反应条件
boron trifluoride diethyl etherate; ethane-1,2-dithiol in dichloromethane T=0 - 20°C; 1 h;
参考文献
Yadav; Vishweshwar Rao; Prasad
Synthesis, 2006 , # 22 p. 3888 - 3894
反应条件
1: 78 percent / PhSO2Cl / pyridine / 0 - 20 °C 2: 90 percent / Pd/C / tetrahydrofuran / 4 h / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 47, # 26 p. 4393 - 4395
反应条件
hydrogen; palladium on activated charcoal
参考文献
Dirat; Kouklovsky; Langlois, Yves
Organic Letters, 1999 , vol. 1, # 5 p. 753 - 755
反应条件
hydrogen fluoride in acetonitrile T=0 - 20°C; Inert atmosphere;
参考文献
Yang, Peng-Yu; Liu, Kai; Ngai, Mun Hong; Lear, Martin J.; Wenk, Markus R.; Yao, Shao Q.
Journal of the American Chemical Society, 2010 , vol. 132, # 2 p. 656 - 666
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran T=-90°C; 0.166667 h;
参考文献
Pommier; Pons
Synthesis, 1994 , # SPEC. ISS. p. 1294 - 1300
反应条件
1.1: 76 percent / DIBAH / toluene / 1 h / -78 °C 2.1: sodium amide / tetrahydrofuran / 4 h / Heating 2.2: tetrahydrofuran / -78 °C 3.1: mCPBA / diethyl ether / 1 h / 20 °C 3.2: aq. HCl / tetrahydrofuran / 2 h / 20 °C 4.1: NaClO2; NaH2PO4; 2-methyl-2-butene / 2-methyl-propan-2-ol / 24 h / 20 °C 5.1: 1.13 g / PhSO2Cl; pyridine 6.1: 99 percent / H2 / Pd/C View Scheme
参考文献
Organic Letters, , vol. 1, # 5 p. 753 - 755
