1-(2-羟基乙氧基)甲基-5-甲基尿嘧啶合成路线 （共 21 条）
参考文献
ALT SOLUTIONS, INC.
Patent: WO2007/106561 A2, 2007 ;
Location in patent: Page/Page column 60 ;
反应条件
ammonia in methanol T=4 - 5°C; 120 h;
参考文献
Schroeder, Alan C.; Hughes, Robert G.; Bloch, Alexander
Journal of Medicinal Chemistry, 1981 , vol. 24, # 9 p. 1078 - 1083
反应条件
1: 5-methyl-2,4(1H,3H)-pyrimidinedione With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane 2 h; Heating; 2: 1,3-dioxacyclopentane With trimethylsilyl trifluoromethanesulfonate in acetonitrile T=-45 - 20°C; Further stages.;
参考文献
Van Daele, Ineke; Munier-Lehmann, Helene; Froeyen, Matheus; Balzarini, Jan; Van Calenbergh, Serge
Journal of Medicinal Chemistry, 2007 , vol. 50, # 22 p. 5281 - 5292
反应条件
sodium in methanol 2 h; Ambient temperature;
参考文献
Zhang, Xinying; Amer, Adel; Fan, Xuesen; Balzarini, Jan; Neyts, Johan; De Clercq, Erik; Prichard, Mark; Kern, Earl; Torrence, Paul F.
Bioorganic Chemistry, 2007 , vol. 35, # 3 p. 221 - 232
反应条件
chloro-trimethyl-silane; potassium iodide in acetonitrile 16 h; Ambient temperature; Yield given;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 43, # 1 p. 142 - 143
反应条件
1: 76 percent / toluene / 24 h / Ambient temperature 2: 94 percent / NH3 / methanol / 120 h / 4 - 5 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 24, # 9 p. 1078 - 1083
反应条件
1: chlorotrimethylsilane / Heating 2: 1.) acetonitrile, 0 degC, 2.) 0 degC to R.T. 2 h 3: 93 percent / Na / methanol / 2 h / Ambient temperature View Scheme
参考文献
Canadian Journal of Chemistry, , vol. 60, # 5 p. 547 - 553
反应条件
1: 34 percent / Na2CO3 / CH2Cl2 / 24 h / Ambient temperature 2: 17 percent / 2M NaOH / 26 h / Ambient temperature View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 18, # 5 p. 947 - 951
反应条件
1: 1.) acetonitrile, 0 degC, 2.) 0 degC to R.T. 2 h 2: 93 percent / Na / methanol / 2 h / Ambient temperature View Scheme
参考文献
Canadian Journal of Chemistry, , vol. 60, # 5 p. 547 - 553
反应条件
sodium hydroxide 26 h; Ambient temperature;
参考文献
Abrams; Ho; Chu
Journal of Heterocyclic Chemistry, 1981 , vol. 18, # 5 p. 947 - 951
