1-(2-羟基乙氧基)甲基-5-甲基尿嘧啶合成路线 （共 21 条）
参考文献
Journal of Pharmaceutical Sciences, , vol. 77, # 11 p. 939 - 943
反应条件
1: 90 percent / imidazole / dimethylformamide / 14 h / Ambient temperature 2: 1.) LDA / 1.) THF, -70 deg C, 1 h, 2.) -70 deg C, 1 h 3: 65 percent / AcOH, H2O / tetrahydrofuran / 14 h / Ambient temperature View Scheme
参考文献
Tanaka; Baba; Hayakawa; Sakamaki; Miyasaka; Ubasawa; Takashima; Sekiya; Nitta; Shigeta; Walker; Balzarini; De Clercq
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 349 - 357
反应条件
1: 90 percent / imidazole / dimethylformamide / 14 h / Ambient temperature 2: 1.) LDA, 2.) α-bromoacetophenone / 1.) THF, -70 deg C, 1 h, 2.) -70 deg C, 1 h 3: 73 percent / AcOH, H2O / tetrahydrofuran / 14 h / Ambient temperature View Scheme
参考文献
Tanaka; Baba; Hayakawa; Sakamaki; Miyasaka; Ubasawa; Takashima; Sekiya; Nitta; Shigeta; Walker; Balzarini; De Clercq
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 349 - 357
反应条件
1: 90 percent / imidazole / dimethylformamide / 14 h / Ambient temperature 2: 1.) LDA / 1.) THF, -70 deg C, 1 h, 2.) -70 deg C, 1 h 3: 100 percent / NaBH4 / ethanol / 14 h / Ambient temperature 4: 92 percent / pyridine / 16 h / Ambient temperature 5: 86 percent / H2 / 10percent Pd-C / ethanol / 6 h / 55 °C / 760 Torr 6: 72 percent / AcOH, H2O / tetrahydrofuran / 14 h / Ambient temperature View Scheme
参考文献
Tanaka; Baba; Hayakawa; Sakamaki; Miyasaka; Ubasawa; Takashima; Sekiya; Nitta; Shigeta; Walker; Balzarini; De Clercq
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 349 - 357
反应条件
1: 90 percent / imidazole / dimethylformamide / 14 h / Ambient temperature 2: 1.) LDA, 2.) p-toluenesulfonyl chloride / 1.) THF, -70 deg C, 1 h, 2.) -70 deg C, 1 h 3: 84 percent / AcOH, H2O / tetrahydrofuran / 14 h / Ambient temperature View Scheme
参考文献
Tanaka; Baba; Hayakawa; Sakamaki; Miyasaka; Ubasawa; Takashima; Sekiya; Nitta; Shigeta; Walker; Balzarini; De Clercq
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 349 - 357
反应条件
1: 89 percent / imidazole / dimethylformamide / Ambient temperature 2: 1.) LDA / 1.) THF, from -78 deg C to -70 deg C, 1 h, 2.) THF, -78 deg C, 30 min 3: 75 percent / n-Bu4NF / tetrahydrofuran / 0.5 h / Ambient temperature View Scheme
参考文献
Goudgaon, Naganna M.; Schinazi, Raymond F.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 11 p. 3305 - 3309
反应条件
1: 90 percent / imidazole / dimethylformamide / 14 h / Ambient temperature 2: 1.) LDA / 1.) THF, -70 deg C, 1 h, 2.) -70 deg C, 1 h 3: concd. HCl / 2 h / Ambient temperature; pH 1.2 View Scheme
参考文献
Tanaka; Baba; Hayakawa; Sakamaki; Miyasaka; Ubasawa; Takashima; Sekiya; Nitta; Shigeta; Walker; Balzarini; De Clercq
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 349 - 357
反应条件
1: 90 percent / imidazole / dimethylformamide / 14 h / Ambient temperature 2: 1.) LDA / 1.) THF, -70 deg C, 1 h, 2.) -70 deg C, 1 h 3: concd. HCl / 2 h / Ambient temperature; pH 1.2 View Scheme
参考文献
Tanaka; Baba; Hayakawa; Sakamaki; Miyasaka; Ubasawa; Takashima; Sekiya; Nitta; Shigeta; Walker; Balzarini; De Clercq
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 349 - 357
反应条件
1: imidazole / dimethylformamide 2: 1) lithium diisopropylamide, 2) I2 / 1) THF, below -70 deg C, 2) -70 deg C, 1 h 3: aq. AcOH / tetrahydrofuran View Scheme
参考文献
Miyasaka; Tanaka; Baba; Hayakawa; Walker; Balzarini; De Qlercq
Journal of Medicinal Chemistry, 1989 , vol. 32, # 12 p. 2507 - 2509
反应条件
1: 90 percent / imidazole / dimethylformamide / 14 h / Ambient temperature 2: 1.) LDA / 1.) THF, -70 deg C, 1 h, 2.) -70 deg C, 1 h 3: concd. HCl / 2 h / Ambient temperature; pH 1.2 View Scheme
参考文献
Tanaka; Baba; Hayakawa; Sakamaki; Miyasaka; Ubasawa; Takashima; Sekiya; Nitta; Shigeta; Walker; Balzarini; De Clercq
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 349 - 357
