3,4-二氢氮杂卓并[3,4-b]吲哚-1,5(2H,10H)-二酮合成路线 （共 6 条）
反应条件
methanesulfonic acid; phosphorus pentoxide
T=110°C; 1.5 h;
参考文献
Sharma, Vasudha; Tepe, Jetze J.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 16 p. 4319 - 4321
反应条件
1: 1-hydroxy-benzptriazole; DCC; Et3N / dimethylformamide; dioxane; CH2Cl2 / 20 °C
2: KOH / dioxane; H2O / 20 h / 20 °C
3: P2O5; methanesulfonic acid / 1.25 h / 80 °C
View Scheme
参考文献
Kaiser, Hanns Martin; Lo, Wei Fun; Riahi, Abdol Majid; Spannenberg, Anke; Beller, Matthias; Tse, Man Kin
Organic Letters, 2006 , vol. 8, # 25 p. 5761 - 5764
反应条件
1: With dihydroxy-(furan-2-yl)-borane; tetrakis(triphenylphosphine) palladium(0); water; sodium carbonate in ethanol; toluene
T=70°C; Suzuki coupling; Inert atmosphere;
2: With silica gel
T=100°C; 1 h; Inert atmosphere;
参考文献
Mangu, Naveenkumar; Spannenberg, Anke; Beller, Matthias; Tse, Man-Kin
Synlett, 2010 , # 2 p. 211 - 214
反应条件
1: KOH / dioxane; H2O / 20 h / 20 °C
2: P2O5; methanesulfonic acid / 1.25 h / 80 °C
View Scheme
参考文献
Kaiser, Hanns Martin; Lo, Wei Fun; Riahi, Abdol Majid; Spannenberg, Anke; Beller, Matthias; Tse, Man Kin
Organic Letters, 2006 , vol. 8, # 25 p. 5761 - 5764
参考文献
Suzuki, Hideharu; Shinpo, Kayoko; Yamazaki, Towako; Niwa, Sachiko; Yokoyama, Yuusaku; Murakami, Yasuoki
Heterocycles, 1996 , vol. 42, # 1 p. 83 - 86
反应条件
sodium tetrahydroborate in ethanol
T=20°C; 14 h;
参考文献
Kaiser, Hanns Martin; Zenz, Ivo; Wei, Fun Lo; Spannenberg, Anke; Schroeder, Kristin; Jiao, Haijun; Goerdes, Dirk; Beller, Matthias; Man, Kin Tse
Journal of Organic Chemistry, 2007 , vol. 72, # 23 p. 8847 - 8858
