(1R,2R)-(-)-N,N'-二甲基-1,2-环己二胺合成路线 （共 15 条）
反应条件
1.1: triphenylphosphine; diethylazodicarboxylate / dichloromethane / 6 h / 20 °C / |Cooling with ice 2.1: ammonium chloride / water / 5 h / 110 °C / |Sealed tube 3.1: (2S,3S)-2,3-dihydroxybutanedioic acid / ethanol / 1 h / 20 °C / |Reflux; |Resolution of racemate 3.2: 20 °C / pH 9-10 / |Reflux; |Resolution of racemate View Scheme
参考文献
Journal of Chemical Research, , vol. 37, # 4 p. 191 - 192
参考文献
Arjan, Hitesh; Boyd, Ewan; Coumbarides, Gregory S.; Eames, Jason; Jones, Ray V. H.; Stenson, Rachel A.; Suggate, Michael J.
Tetrahedron Letters, 2005 , vol. 46, # 11 p. 1921 - 1925
反应条件
CuI; potassium carbonate in ethyl acetate
参考文献
Buchwald, Stephen L.; Klapars, Artis; Antilla, Jon C.; Job, Gabriel E.; Wolter, Martina; Kwong, Fuk Y.; Nordmann, Gero; Hennessy, Edward J.
Patent: US2003/65187 A1, 2003 ;
反应条件
CuI; potassium carbonate in ethyl acetate
参考文献
Buchwald, Stephen L.; Klapars, Artis; Antilla, Jon C.; Job, Gabriel E.; Wolter, Martina; Kwong, Fuk Y.; Nordmann, Gero; Hennessy, Edward J.
Patent: US2003/65187 A1, 2003 ;
反应条件
CuI; potassium carbonate in ethyl acetate
参考文献
Buchwald, Stephen L.; Klapars, Artis; Antilla, Jon C.; Job, Gabriel E.; Wolter, Martina; Kwong, Fuk Y.; Nordmann, Gero; Hennessy, Edward J.
Patent: US2003/65187 A1, 2003 ;
