6-(三氟甲基)-1-茚酮合成路线 （共 5 条）
反应条件
n-butyllithium in tetrahydrofuran; hexane 0.25 h;
参考文献
US2005/261310 A1, ;
Page/Page column 22 ;
US 20050261310 A1
反应条件
chlorosulfonic acid T=0°C; Friedel-Crafts reaction; 1 h;
参考文献
Tetrahedron, , vol. 63, # 2 p. 389 - 395
反应条件
1: H2O / acetonitrile / 0.5 h / 120 °C / microwave irradiation 2: 23 percent / chlorosulfonic acid / 1 h / 0 °C View Scheme
参考文献
Tetrahedron, , vol. 63, # 2 p. 389 - 395
反应条件
1: 77 percent / triethylammonium formate 2: H2O / acetonitrile / 0.5 h / 120 °C / microwave irradiation 3: 23 percent / chlorosulfonic acid / 1 h / 0 °C View Scheme
参考文献
Tetrahedron, , vol. 63, # 2 p. 389 - 395
反应条件
1: With sodium tetrahydroborate in tetrahydrofuran; methanol
2.5 h;
2: With water; ammonium chloride in tetrahydrofuran; methanol
参考文献
Xue, Chu-Biao; Cao, Ganfeng; Huang, Taisheng; Chen, Lihua; Zhang, Ke; Wang, Anlai; Meloni, David; Anand, Rajan; Glenn, Joseph; Metcalf, Brian W.
Patent: US2005/261310 A1, 2005 ;
Location in patent: Page/Page column 22 ;
US 20050261310 A1
