5-吡啶基-2-氨基-1,3,4-噻二唑合成路线 （共 11 条）
反应条件
1: With sulfuric acid T=100°C; 3 h; 2: With sodium hydroxide in water T=23°C; pH=Ca.9;
参考文献
US2012/53146 A1, ;
Paragraph 0093; 0094 ;
反应条件
trichlorophosphate T=0 - 5°C; 4.5 h; Reflux;
参考文献
Journal of Chemical Research, , vol. 35, # 12 p. 703 - 706
反应条件
1.1: sulfuric acid / 10 h / Reflux 2.1: hydrazine hydrate / 0 °C 3.1: hydrogenchloride / water / Reflux 4.1: sulfuric acid / 2 h / 20 °C 4.2: 2 h / Cooling with ice View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 10, # 9 p. 1785 - 1794
反应条件
1.1: hydrazine hydrate / 0 °C 2.1: hydrogenchloride / water / Reflux 3.1: sulfuric acid / 2 h / 20 °C 3.2: 2 h / Cooling with ice View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 10, # 9 p. 1785 - 1794
反应条件
1.1: hydrogenchloride / water / Reflux 2.1: sulfuric acid / 2 h / 20 °C 2.2: 2 h / Cooling with ice View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 10, # 9 p. 1785 - 1794
反应条件
water; iron(III) chloride
参考文献
Journal of Organic Chemistry, , vol. 20, p. 976,978
反应条件
1: pyridine / 20 °C 2: sulfuric acid / 0.5 h / 40 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 7 p. 2456 - 2459
反应条件
acetic acid Behandeln des Reaktionsprodukts mit konz. H2SO4;
参考文献
Farmaco, Edizione Scientifica, , vol. 13, p. 187,196
反应条件
1.) pyridine, 10 deg C, 30 min; 2.) methanesulfonic acid, reflux, 5 h; Yield given. Multistep reaction;
参考文献
Farmaco, Edizione Scientifica, , vol. 41, # 10 p. 737 - 746
参考文献
Journal of Organic Chemistry, , vol. 20, p. 976,978
