1: 98.7 percent / acetic acid / 6 h / 60 °C 2: Na, propanol / 1 h / Heating 3: conc. HCl / propan-2-ol; H2O / 6 h / 20 - 130 °C 4: 1.) LDA / 1.) THF, hexane, -75 deg C, 20 min, 2.) THF, hexane, -75 deg C, 30 min View Scheme

1: Et3N / CHCl3 / 1 h / 20 °C 2: 1.) LDA / 1.) THF, hexane, -75 deg C, 20 min, 2.) THF, hexane, -75 deg C, 30 min View Scheme

1: Na, propanol / 1 h / Heating 2: conc. HCl / propan-2-ol; H2O / 6 h / 20 - 130 °C 3: 1.) LDA / 1.) THF, hexane, -75 deg C, 20 min, 2.) THF, hexane, -75 deg C, 30 min View Scheme

lithium diisopropyl amide 1.) THF, hexane, -75 deg C, 20 min, 2.) THF, hexane, -75 deg C, 30 min; Yield given. Multistep reaction;