4-甲氧基-3-甲基苯甲酸合成路线 （共 42 条）
反应条件
1: (COCl)2; DMF / CH2Cl2 2: diethyl ether / 0 °C 3: aq. Ag2O / dioxane View Scheme
参考文献
Young, Jonathan R.; Huang, Song X.; Chen, Irene; Walsh, Thomas F.; DeVita, Robert J.; Wyvratt Jr., Matthew J.; Goulet, Mark T.; Ren, Ning; Lo, Jane; Yang, Yi Tien; Yudkovitz, Joel B.; Cheng, Kang; Smith, Roy G.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 15 p. 1723 - 1727
反应条件
hydrogen bromide in water; acetic acid T=120°C; 24 h;
参考文献
ASTEX THERAPEUTICS LIMITED
Patent: WO2007/72041 A1, 2007 ;
Location in patent: Page/Page column 57 ;
WO 2007/072041 A1
反应条件
1: KMnO4; alkali 2: potash / durch Schmelzen View Scheme
参考文献
Schall
Chemische Berichte, 1879 , vol. 12, p. 818,821
反应条件
sulfuric acid 4 h; Heating / reflux;
参考文献
Dainippon Sumitomo Pharma Co., Ltd.; AstraZeneca AB
Patent: EP1728792 A1, 2006 ;
Location in patent: Page/Page column 139 ;
反应条件
1: SOCl2 / diethyl ether 2: 2.) SOCl2 / 2.) Et2O 3: 90 percent / s-BuLi / 1.) Et2O, 0 deg C, 2.) Et2O 4: 2.) H3O(1+) / 1.) THF View Scheme
参考文献
Baker, Raymond; O'Mahony, Mary J.; Swain, Christopher J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 1623 - 1634
反应条件
potassium permanganate
参考文献
Schall
Chemische Berichte, 1879 , vol. 12, p. 818,821
反应条件
bromine in 1,4-dioxane
T=20°C; 168 h;
参考文献
Tietze, Lutz F.; Stewart, Scott G.; Polomska, Marta E.; Modi, Andrea; Zeeck, Axel
Chemistry - A European Journal, 2004 , vol. 10, # 20 p. 5233 - 5242
反应条件
1: 84 percent / Br2 / dioxane / 168 h / 20 °C
2: 72 percent / LiAlH4 / tetrahydrofuran; diethyl ether / 0.5 h / 0 °C
3: 87 percent / MnO2 / CH2Cl2 / 12 h / 20 °C
View Scheme
参考文献
Tietze, Lutz F.; Stewart, Scott G.; Polomska, Marta E.; Modi, Andrea; Zeeck, Axel
Chemistry - A European Journal, 2004 , vol. 10, # 20 p. 5233 - 5242
反应条件
1: 84 percent / Br2 / dioxane / 168 h / 20 °C
2: 72 percent / LiAlH4 / tetrahydrofuran; diethyl ether / 0.5 h / 0 °C
3: 87 percent / MnO2 / CH2Cl2 / 12 h / 20 °C
4: aq. m-CPBA / CH2Cl2 / 12 h / 20 °C
5: 1.68 g / K2CO3 / methanol / 0.25 h / 20 °C
View Scheme
参考文献
Tietze, Lutz F.; Stewart, Scott G.; Polomska, Marta E.; Modi, Andrea; Zeeck, Axel
Chemistry - A European Journal, 2004 , vol. 10, # 20 p. 5233 - 5242
反应条件
1: 90 percent / SOCl2 / 24 h / 25 °C
2: CH2Cl2 / 2 h / 25 °C
3: SOCl2 / CH2Cl2 / 0.5 h / 25 °C
View Scheme
参考文献
Smith, Amos B.; Schow, Steven R.; Bloom, Jonathan D.; Thompson, Andrew S.; Winzenberg, Kevin N.
Journal of the American Chemical Society, 1982 , vol. 104, # 14 p. 4015 - 4018
